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Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

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  • Andrea Ganna
  • Karin J H Verweij
  • Michel G Nivard
  • Robert Maier
  • Robbee Wedow
  • Alexander S Busch
  • Abdel Abdellaoui
  • Shengru Guo
  • J Fah Sathirapongsasuti
  • Paul Lichtenstein
  • Sebastian Lundström
  • Niklas Långström
  • Adam Auton
  • Kathleen Mullan Harris
  • Gary W Beecham
  • Eden R Martin
  • Alan R Sanders
  • John R B Perry
  • Benjamin M Neale
  • Brendan P Zietsch
  • 23andMe Research Team
Vis graf over relationer

Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 individuals, revealing five loci significantly associated with same-sex sexual behavior. In aggregate, all tested genetic variants accounted for 8 to 25% of variation in same-sex sexual behavior, only partially overlapped between males and females, and do not allow meaningful prediction of an individual's sexual behavior. Comparing these GWAS results with those for the proportion of same-sex to total number of sexual partners among nonheterosexuals suggests that there is no single continuum from opposite-sex to same-sex sexual behavior. Overall, our findings provide insights into the genetics underlying same-sex sexual behavior and underscore the complexity of sexuality.

OriginalsprogEngelsk
TidsskriftScience
Vol/bind365
Udgave nummer6456
ISSN0036-8075
DOI
StatusUdgivet - 30 aug. 2019

Bibliografisk note

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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