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Lamotrigine increases the number of BrdU-labeled cells in the rat hippocampus

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  1. Structural asymmetry of cortical visual areas is related to ocular dominance

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  2. Expression of presynaptic markers in a neurodevelopmental animal model with relevance to schizophrenia

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  3. Navigation with a sensory substitution device in congenitally blind individuals

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  4. Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine

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  5. Recruitment of the middle temporal area by tactile motion in congenital blindness

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  1. Questionnaires vs Interviews for the Assessment of Global Functional Outcomes After Traumatic Brain Injury

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  2. Nærdødsoplevelser

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  3. Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients: a CENTER-TBI study

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Vis graf over relationer
Antidepressant medication and electroconvulsive therapy stabilize mood symptoms and increase hippocampal neurogenesis. We examined whether lamotrigine, suggested to give rise to mood-stabilizing and antidepressant effects in addition to its antiepileptic properties, also increases the number of newborn cells in rat hippocampus. Rats (on day P21) received lamotrigine, valproate, or saline intraperitoneally once daily for 7 days. All animals received four intraperitoneal injections of bromodeoxyuridine (BrdU) on day P28 and were sacrificed the next day. Quantification of BrdU-labeled cells in the granule cell layer of the dentate gyrus showed an increased number of newborn cells in rats receiving lamotrigine (42.6 ± 3.5 cells/slice) compared with valproate (31.6 ± 2.8) and controls (32.2 ± 3.1; P
OriginalsprogEngelsk
TidsskriftNeuroReport
Vol/bind22
Udgave nummer2
Sider (fra-til)97-100
Antal sider4
ISSN0959-4965
DOI
StatusUdgivet - 26 jan. 2011

ID: 32712768