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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Lactoferrin, myeloperoxidase, lysozyme and eosinophil cationic protein in exudate in delayed type hypersensitivity

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  1. Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. 2019 ARIA Care pathways for allergen immunotherapy

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  3. An EAACI position paper on the investigation of perioperative immediate hypersensitivity reactions

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  4. Cesarean delivery and risk of atopic dermatitis

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  1. Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Virulent coliphages in 1-year-old children fecal samples are fewer, but more infectious than temperate coliphages

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Bacteremia and urogenital infection with Actinomyces urogenitalis following prolonged urinary retention

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Antibiotic exposure in infancy and development of BMI and body composition in childhood

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Vis graf over relationer

A skin window technique was used to study the morphology of leucocytes in upper dermis and exudate during nickel challenge in patients with contact allergy to nickel. Contact allergic patients and healthy volunteers tested with a skin widow without addition of nickel to the chamber medium served as controls. The morphology of the leucocytes in dermis was studied in biopsies taken 8, 24, or 48 h after skin window application, and in a parallel test the morphology of the exudate was examined by sequential collection of the chamber medium during a 48 h period. The infiltrate in dermis of contact allergic patients with nickel challenge in the chamber medium showed a time-dependent increase of mononuclear cells, eosinophils and basophils and a concomitant decrease of polymorphonuclear granulocytes, characteristic of a combined specific and unspecific inflammation. The morphology of the exudate in contact allergic patients exposed to nickel showed a dominance of polymorphonuclear granulocytes throughout the study period, while mononuclear cells, eosinophils and basophils were detected at a much lower quantity and with a considerable delay. Further, we studied the kinetics of the leucocyte granule proteins: lactoferrin, myeloperoxidase, lysozyme and eosinophil cationic protein in exudate fluid in a parallel test. A significant higher flux was found for all during the second day of allergen exposure compared to contact allergic patients without allergen challenge as well as normal volunteers. The increased protein fluxes were not accompanied by an increased flux of polymorphonuclear granulocytes in the exudate.(ABSTRACT TRUNCATED AT 250 WORDS)

OriginalsprogEngelsk
TidsskriftAllergy
Vol/bind43
Udgave nummer2
Sider (fra-til)139-45
Antal sider7
ISSN0105-4538
StatusUdgivet - feb. 1988

ID: 46041899