Lack of relationship between genotype and virulence in Candida species

Judith Díaz-García, Maiken C Arendrup, Rafael Cantón, Julio García-Rodríguez, Elia Gómez García de la Pedrosa, Gabriella Parisi, Javier Pemán, Brunella Posteraro, Maurizio Sanguinetti, Daniel Archimedes Da Matta, Arnaldo L Colombo, Patricia Muñoz, Carlos Sánchez-Carrillo, Jesús Guinea, Pilar Escribano


BACKGROUND: The virulence of isolates among different Candida species causing candidemia may play a role in the prognosis of the patients. Furthermore, the potential relationship between genotype and virulence is still unclear and need to be further studied.

AIMS: We aim to assess the relationship between genotype and virulence in Candida species using a Galleria mellonella larvae infection model.

METHODS: One hundred and ninety-four isolates from 68 clusters (Candida albicans, 114/41; Candida parapsilosis, 74/24; Candida tropicalis, 6/3) were compared against the same number of each species singleton genotypes in terms of survival of G. mellonella larvae.

RESULTS: The median of survival and the IQR ranges of clusters and singleton were as follows: C. albicans (2 days, IQR 1.5-2 vs. 2 days, IQR 1-2.25), C. parapsilosis (2 days, IQR 1.5-2.6 vs. 2 days, IQR 2-3.3), and C. tropicalis (1 day, IQR 1-3.5 vs. 2 days, IQR 2-3.5; p<0.05). High intra-cluster variability in terms of median of survival was found regardless the species.

CONCLUSIONS: No relationship between genotype and virulence in Candida was observed with the G. mellonella model.

TidsskriftRevista iberoamericana de micologia
Udgave nummer1
Sider (fra-til)9-11
Antal sider3
StatusUdgivet - 29 dec. 2021


  • Candida albicans
  • Candida parapsilosis
  • Candida tropicalis
  • Galleria mellonella
  • Genotyping
  • Virulence


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