Lack of effect of zinc supplementation on antipyrine clearance in alcoholic liver disease

K Grønbaek; H Friis; M Feldman; J Sonne; P B Andreasen

doi:10.1007/BF00203785

Lack of effect of zinc supplementation on antipyrine clearance in alcoholic liver disease

K Grønbaek, H Friis, M Feldman, J Sonne, P B Andreasen

2 Citationer (Scopus)

Abstract

METHODS: The effect of zinc supplementation on antipyrine clearance was evaluated in 14 outpatients with stable alcoholic liver disease, of whom nine had biopsy proven alcoholic cirrhosis.

RESULTS: There was no change in antipyrine clearance after 14 days of zinc supplementation (median 12.5 vs 12.9 ml.min-1). However, a significant increase in P-prothrombin-proconvertin was found. There was a positive correlation between S-zinc and antipyrine clearance at inclusion (rs = 0.76) as well as after zinc supplementation (rs = 0.72).

CONCLUSION: No effect of zinc supplementation on antipyrine clearance was found. The positive correlation between S-zinc and antipyrine clearance could be due to the confounding effect of alcoholic liver disease.

Originalsprog	Engelsk
Tidsskrift	European Journal of Clinical Pharmacology
Vol/bind	49
Udgave nummer	5
Sider (fra-til)	397-9
Antal sider	3
ISSN	0031-6970
DOI	https://doi.org/10.1007/BF00203785
Status	Udgivet - 1996
Udgivet eksternt	Ja

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10.1007/BF00203785

Citationsformater

@article{c6dd1954e1784015b5d6bf703fb23e03,

title = "Lack of effect of zinc supplementation on antipyrine clearance in alcoholic liver disease",

abstract = "METHODS: The effect of zinc supplementation on antipyrine clearance was evaluated in 14 outpatients with stable alcoholic liver disease, of whom nine had biopsy proven alcoholic cirrhosis.RESULTS: There was no change in antipyrine clearance after 14 days of zinc supplementation (median 12.5 vs 12.9 ml.min-1). However, a significant increase in P-prothrombin-proconvertin was found. There was a positive correlation between S-zinc and antipyrine clearance at inclusion (rs = 0.76) as well as after zinc supplementation (rs = 0.72).CONCLUSION: No effect of zinc supplementation on antipyrine clearance was found. The positive correlation between S-zinc and antipyrine clearance could be due to the confounding effect of alcoholic liver disease.",

keywords = "Adjuvants, Immunologic/administration & dosage, Adult, Aged, Alkaline Phosphatase/blood, Antipyrine/blood, Bilirubin/blood, Factor VII/analysis, Female, Food, Fortified, Humans, Liver Cirrhosis, Alcoholic/blood, Male, Middle Aged, Outpatients, Prothrombin/analysis, Regression Analysis, Serum Albumin/analysis, Spectrophotometry, Atomic, Tablets, Enteric-Coated, Zinc Sulfate/administration & dosage",

author = "K Gr{\o}nbaek and H Friis and M Feldman and J Sonne and Andreasen, {P B}",

year = "1996",

doi = "10.1007/BF00203785",

language = "English",

volume = "49",

pages = "397--9",

journal = "European Journal of Clinical Pharmacology",

issn = "0031-6970",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "5",

}

TY - JOUR

T1 - Lack of effect of zinc supplementation on antipyrine clearance in alcoholic liver disease

AU - Grønbaek, K

AU - Friis, H

AU - Feldman, M

AU - Sonne, J

AU - Andreasen, P B

PY - 1996

Y1 - 1996

N2 - METHODS: The effect of zinc supplementation on antipyrine clearance was evaluated in 14 outpatients with stable alcoholic liver disease, of whom nine had biopsy proven alcoholic cirrhosis.RESULTS: There was no change in antipyrine clearance after 14 days of zinc supplementation (median 12.5 vs 12.9 ml.min-1). However, a significant increase in P-prothrombin-proconvertin was found. There was a positive correlation between S-zinc and antipyrine clearance at inclusion (rs = 0.76) as well as after zinc supplementation (rs = 0.72).CONCLUSION: No effect of zinc supplementation on antipyrine clearance was found. The positive correlation between S-zinc and antipyrine clearance could be due to the confounding effect of alcoholic liver disease.

AB - METHODS: The effect of zinc supplementation on antipyrine clearance was evaluated in 14 outpatients with stable alcoholic liver disease, of whom nine had biopsy proven alcoholic cirrhosis.RESULTS: There was no change in antipyrine clearance after 14 days of zinc supplementation (median 12.5 vs 12.9 ml.min-1). However, a significant increase in P-prothrombin-proconvertin was found. There was a positive correlation between S-zinc and antipyrine clearance at inclusion (rs = 0.76) as well as after zinc supplementation (rs = 0.72).CONCLUSION: No effect of zinc supplementation on antipyrine clearance was found. The positive correlation between S-zinc and antipyrine clearance could be due to the confounding effect of alcoholic liver disease.

KW - Adjuvants, Immunologic/administration & dosage

KW - Adult

KW - Aged

KW - Alkaline Phosphatase/blood

KW - Antipyrine/blood

KW - Bilirubin/blood

KW - Factor VII/analysis

KW - Female

KW - Food, Fortified

KW - Humans

KW - Liver Cirrhosis, Alcoholic/blood

KW - Male

KW - Middle Aged

KW - Outpatients

KW - Prothrombin/analysis

KW - Regression Analysis

KW - Serum Albumin/analysis

KW - Spectrophotometry, Atomic

KW - Tablets, Enteric-Coated

KW - Zinc Sulfate/administration & dosage

U2 - 10.1007/BF00203785

DO - 10.1007/BF00203785

M3 - Journal article

C2 - 8866636

SN - 0031-6970

VL - 49

SP - 397

EP - 399

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

IS - 5

ER -

Lack of effect of zinc supplementation on antipyrine clearance in alcoholic liver disease

Abstract

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