Lack of effect of ivermectin on prepatent guinea-worm: A single-blind, Placebo-controlled trial

A. Issaka-Tinorgah, P. Magnussen*, P. Bloch, A. Yakubu

*Corresponding author af dette arbejde
14 Citationer (Scopus)

Abstract

The effect of ivermectin on prepatent guinea-worm was tested in a single-blind placebo-controlled trial; 400 adults were randomly allocated to a single dose of ivermectin (150 µg/kg) or placebo. Fifty-four of the 385 participants who were followed for 15 months developed a total of 69 emergent guinea-worms. There was no significant differencein the proportion of persons with emergent guinea-worms between the 2 treatment groups; 58% appeared in males. 80% of emergent guinea-worms were located below the knee. Migration of guinea-worms in the tissues was not affected. It is concluded that ivermectin has no effect on prepatent guinea-worms nor does it disturb their migration pattern. No adverse reaction to treatment was seen. It appears that ivermectin can be used safely as mass chemotherapy against onchocerciasis and lymphatic filariasis in areas where guinea-worm is also endemic.

OriginalsprogEngelsk
TidsskriftTransactions of the Royal Society of Tropical Medicine and Hygiene
Vol/bind88
Udgave nummer3
Sider (fra-til)346-348
Antal sider3
ISSN0035-9203
DOI
StatusUdgivet - 1994
Udgivet eksterntJa

Fingeraftryk

Dyk ned i forskningsemnerne om 'Lack of effect of ivermectin on prepatent guinea-worm: A single-blind, Placebo-controlled trial'. Sammen danner de et unikt fingeraftryk.

Citationsformater