Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity

T Berentzen, S I I Kring, C Holst, E Zimmermann, T Jess, T Hansen, O Pedersen, S Toubro, A Astrup, T I A Sørensen

85 Citationer (Scopus)


CONTEXT: A common variant in the first intron of FTO (rs9939609, T/A) is associated with fatness in Caucasians.

OBJECTIVE: FTO may regulate energy homeostasis through the hypothalamus, and we hypothesized that AA-genotypes of rs9939609 FTO have lower energy expenditure and/or a lower level of physical activity.

METHODS: The study population included all obese young men (body mass index > or = 31 kg/m(2)) at the mandatory draft board examinations in the Copenhagen area from 1943 to 1977 and a randomly selected control group from this population. Subgroups of 234 obese and 323 controls were examined in 1998-2000 (median age 48 yr). Fat mass (FM), lean body mass (LBM), leisure-time physical activity (LTPA), maximum oxygen uptake (VO(2)max), resting energy expenditure (REE), and glucose-induced thermogenesis (GIT) were measured. The FTO rs9939609 variant was genotyped. A recessive transmission mode fit the data best. Logistic regression was used to assess the odds ratios of the AA-genotype in relation to LTPA, VO(2)max, REE, and GIT.

RESULTS: The AA-genotype of FTO rs9939609 had higher REE in the age-adjusted model, but the association was eliminated when adjusting for FM and LBM. The AA-genotype was not associated with LTPA, VO(2)max, or GIT. This was not influenced by adjustment for age, FM, or LBM. The AA-genotype had increased FM, even with adjustment for age, LBM, REE, GIT, VO(2)max, and LTPA. Results were similar for FTO rs8050136 and rs7193144.

CONCLUSIONS: Homozygous carriers of the A-allele of rs9939609 FTO do not have lower REE, GIT, VO(2)max, or LTPA but higher FM, irrespective of LBM, REE, GIT, VO(2)max, and LTPA.

TidsskriftThe Journal of clinical endocrinology and metabolism
Udgave nummer7
Sider (fra-til)2904-8
Antal sider5
StatusUdgivet - jul. 2008


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