Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits

Camilla Helene Andreasen; Mette Sloth Mogensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; Katrine Almind; Lars Hansen; Torben Jørgensen; Oluf Pedersen; Torben Hansen

doi:10.1186/1471-2350-9-118

Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits

Camilla Helene Andreasen, Mette Sloth Mogensen, Knut Borch-Johnsen, Annelli Sandbaek, Torsten Lauritzen, Katrine Almind, Lars Hansen, Torben Jørgensen, Oluf Pedersen, Torben Hansen

13 Citationer (Scopus)

Abstract

Several studies in multiple ethnicities have reported linkage to type 2 diabetes on chromosome 1q21-25. Both PKLR encoding the liver pyruvate kinase and NOS1AP encoding the nitric oxide synthase 1 (neuronal) adaptor protein (CAPON) are positioned within this chromosomal region and are thus positional candidates for the observed linkage peak. The C-allele of PKLR rs3020781 and the T-allele of NOS1AP rs7538490 are reported to strongly associate with type 2 diabetes in various European-descent populations comprising a total of 2,198 individuals with a combined odds ratio (OR) of 1.33 [1.16-1.54] and 1.53 [1.28-1.81], respectively. Our aim was to validate these findings by investigating the impact of the two variants on type 2 diabetes and related quantitative metabolic phenotypes in a large study sample of Danes. Further, we intended to expand the analyses by examining the effect of the variants in relation to overweight and obesity.

Originalsprog	Engelsk
Tidsskrift	B M C Medical Genetics
Vol/bind	9
Sider (fra-til)	118
ISSN	1471-2350
DOI	https://doi.org/10.1186/1471-2350-9-118
Status	Udgivet - 1 jan. 2008

Adgang til dokumentet

10.1186/1471-2350-9-118

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Citationsformater

Andreasen, C. H., Mogensen, M. S., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Almind, K., Hansen, L., Jørgensen, T., Pedersen, O., & Hansen, T. (2008). Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits. B M C Medical Genetics, 9, 118. https://doi.org/10.1186/1471-2350-9-118

Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits. / Andreasen, Camilla Helene; Mogensen, Mette Sloth; Borch-Johnsen, Knut et al.
I: B M C Medical Genetics, Bind 9, 01.01.2008, s. 118.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Andreasen, CH, Mogensen, MS, Borch-Johnsen, K, Sandbaek, A, Lauritzen, T, Almind, K, Hansen, L, Jørgensen, T, Pedersen, O & Hansen, T 2008, 'Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits', B M C Medical Genetics, bind 9, s. 118. https://doi.org/10.1186/1471-2350-9-118

Andreasen CH, Mogensen MS, Borch-Johnsen K, Sandbaek A, Lauritzen T, Almind K et al. Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits. B M C Medical Genetics. 2008 jan. 1;9:118. doi: 10.1186/1471-2350-9-118

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title = "Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits",

abstract = "Several studies in multiple ethnicities have reported linkage to type 2 diabetes on chromosome 1q21-25. Both PKLR encoding the liver pyruvate kinase and NOS1AP encoding the nitric oxide synthase 1 (neuronal) adaptor protein (CAPON) are positioned within this chromosomal region and are thus positional candidates for the observed linkage peak. The C-allele of PKLR rs3020781 and the T-allele of NOS1AP rs7538490 are reported to strongly associate with type 2 diabetes in various European-descent populations comprising a total of 2,198 individuals with a combined odds ratio (OR) of 1.33 [1.16-1.54] and 1.53 [1.28-1.81], respectively. Our aim was to validate these findings by investigating the impact of the two variants on type 2 diabetes and related quantitative metabolic phenotypes in a large study sample of Danes. Further, we intended to expand the analyses by examining the effect of the variants in relation to overweight and obesity.",

author = "Andreasen, {Camilla Helene} and Mogensen, {Mette Sloth} and Knut Borch-Johnsen and Annelli Sandbaek and Torsten Lauritzen and Katrine Almind and Lars Hansen and Torben J{\o}rgensen and Oluf Pedersen and Torben Hansen",

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T1 - Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits

AU - Andreasen, Camilla Helene

AU - Mogensen, Mette Sloth

AU - Borch-Johnsen, Knut

AU - Sandbaek, Annelli

AU - Lauritzen, Torsten

AU - Almind, Katrine

AU - Hansen, Lars

AU - Jørgensen, Torben

AU - Pedersen, Oluf

AU - Hansen, Torben

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Several studies in multiple ethnicities have reported linkage to type 2 diabetes on chromosome 1q21-25. Both PKLR encoding the liver pyruvate kinase and NOS1AP encoding the nitric oxide synthase 1 (neuronal) adaptor protein (CAPON) are positioned within this chromosomal region and are thus positional candidates for the observed linkage peak. The C-allele of PKLR rs3020781 and the T-allele of NOS1AP rs7538490 are reported to strongly associate with type 2 diabetes in various European-descent populations comprising a total of 2,198 individuals with a combined odds ratio (OR) of 1.33 [1.16-1.54] and 1.53 [1.28-1.81], respectively. Our aim was to validate these findings by investigating the impact of the two variants on type 2 diabetes and related quantitative metabolic phenotypes in a large study sample of Danes. Further, we intended to expand the analyses by examining the effect of the variants in relation to overweight and obesity.

AB - Several studies in multiple ethnicities have reported linkage to type 2 diabetes on chromosome 1q21-25. Both PKLR encoding the liver pyruvate kinase and NOS1AP encoding the nitric oxide synthase 1 (neuronal) adaptor protein (CAPON) are positioned within this chromosomal region and are thus positional candidates for the observed linkage peak. The C-allele of PKLR rs3020781 and the T-allele of NOS1AP rs7538490 are reported to strongly associate with type 2 diabetes in various European-descent populations comprising a total of 2,198 individuals with a combined odds ratio (OR) of 1.33 [1.16-1.54] and 1.53 [1.28-1.81], respectively. Our aim was to validate these findings by investigating the impact of the two variants on type 2 diabetes and related quantitative metabolic phenotypes in a large study sample of Danes. Further, we intended to expand the analyses by examining the effect of the variants in relation to overweight and obesity.

U2 - 10.1186/1471-2350-9-118

DO - 10.1186/1471-2350-9-118

M3 - Journal article

C2 - 19111066

SN - 1471-2350

VL - 9

SP - 118

JO - B M C Medical Genetics

JF - B M C Medical Genetics

ER -