Kræftdisponerende mutationer er hyppige hos børn og unge med kræft

Abstract

Germ line mutations causing paediatric cancer predisposition syndromes (PCPSs) are more common than previously anticipated and are now recognised as a significant contributor to the incidence of childhood cancer. Advances in and increased clinical application of next-generation sequencing technologies have led to a rise in paediatric patients undergoing whole genome sequencing (WGS). This review focuses on the potential syndromes/diagnoses, which WGS may reveal in patients with childhood cancers, and highlights the clinical and psychosocial impact of PCPSs.

Bidragets oversatte titelGerm line mutations causing paediatric cancer predisposition syndromes are common in children and adolescents with cancer
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind180
Udgave nummer17
Sider (fra-til)V07170566
ISSN0041-5782
StatusUdgivet - 23 apr. 2018

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