Abstrakt
Germ line mutations causing paediatric cancer predisposition syndromes (PCPSs) are more common than previously anticipated and are now recognised as a significant contributor to the incidence of childhood cancer. Advances in and increased clinical application of next-generation sequencing technologies have led to a rise in paediatric patients undergoing whole genome sequencing (WGS). This review focuses on the potential syndromes/diagnoses, which WGS may reveal in patients with childhood cancers, and highlights the clinical and psychosocial impact of PCPSs.
Bidragets oversatte titel | Germ line mutations causing paediatric cancer predisposition syndromes are common in children and adolescents with cancer |
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Originalsprog | Dansk |
Tidsskrift | Ugeskrift for Laeger |
Vol/bind | 180 |
Udgave nummer | 17 |
Sider (fra-til) | V07170566 |
ISSN | 0041-5782 |
Status | Udgivet - 23 apr. 2018 |