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Region Hovedstaden - en del af Københavns Universitetshospital
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Kinetics of del(7q) driven leukemogenesis in a patient with JAK2 V617F and TET2 mutated chronic myeloproliferative neoplasm

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Chronic myeloid neoplasms have susceptibility to transform into acute myeloid leukemia due to attainment of additional molecular lesions. We here describe the kinetics of a del(7q) driven leukemogenesis in a patient with multiple TET2 mutations and JAK2 V617F mutated chronic myeloproliferative neoplasm. The del(7q) emerged in the accelerated phase of disease, which was preceded by a lag phase of almost three years with normalized peripheral blood cell counts. Our results reveal that the del(7q), independently of other lesions, acts as a leukemic driver in this patient and that the stable long-lasting normalization of peripheral blood cell values concealed pending transformation.
OriginalsprogEngelsk
TidsskriftLeukemia Research Reports
Vol/bind2
Udgave nummer2
Sider (fra-til)51-3
Antal sider3
ISSN2213-0489
DOI
StatusUdgivet - 2013

ID: 42568577