Kinetics of del(7q) driven leukemogenesis in a patient with JAK2 V617F and TET2 mutated chronic myeloproliferative neoplasm

Laura Laine Herborg, Line Nederby, Eigil Kjeldsen, Kirsten Grønbæk, Peter Hokland, Camilla Maria Holm Hansen, Marcus Celik Hansen, Anne Stidsholt Roug

    2 Citationer (Scopus)

    Abstract

    Chronic myeloid neoplasms have susceptibility to transform into acute myeloid leukemia due to attainment of additional molecular lesions. We here describe the kinetics of a del(7q) driven leukemogenesis in a patient with multiple TET2 mutations and JAK2 V617F mutated chronic myeloproliferative neoplasm. The del(7q) emerged in the accelerated phase of disease, which was preceded by a lag phase of almost three years with normalized peripheral blood cell counts. Our results reveal that the del(7q), independently of other lesions, acts as a leukemic driver in this patient and that the stable long-lasting normalization of peripheral blood cell values concealed pending transformation.
    OriginalsprogEngelsk
    TidsskriftLeukemia Research Reports
    Vol/bind2
    Udgave nummer2
    Sider (fra-til)51-3
    Antal sider3
    ISSN2213-0489
    DOI
    StatusUdgivet - 2013

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