### Harvard

Thorsteinsson, B, Fugleberg, S

, Feldt-Rasmussen, B & Binder, C 1985, '

Kinetic models for plasma disappearance of insulin in normal subjects',

*Acta Pharmacologica et Toxicologica*, bind 57, nr. 5, s. 309-16.

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### Bibtex

@article{636c5601771041eebed623598deb2a32,

title = "Kinetic models for plasma disappearance of insulin in normal subjects",

abstract = "Three theoretical kinetic models for plasma disappearance of insulin were examined in six normal men. The models allowed for the existence of non-saturable and/or saturable mechanisms. Constant infusion of porcine insulin at different rates was used to achieve different levels of steady state plasma insulin concentrations, while normoglycaemia was secured by a glucose clamp technique. Appropriate validation procedures demonstrated that one of the three models was superior to the others in describing the relationship between the exogenous insulin infusion rate Iex and the steady state plasma insulin concentration C: Iex = -Iend + k2 X C/(k3 + C), where Iend is the endogenous post-hepatic insulin delivery rate. Thus, only saturable mechanism(s) could be demonstrated. The median value of k2 (the maximal insulin disappearance rate) and k3 (the plasma insulin concentration at which the insulin disappearance rate is half maximal) were 7.31 nmol X min.-1 and 3.89 nmol X 1-1. The median value of k2/k3 (the clearance rate of insulin for infinitesimal plasma insulin concentrations) was 25.0 ml X kg-1 X min.-1. Thus, at physiological levels of plasma insulin concentrations the metabolic clearance rate of insulin is higher than insulin clearance estimates previously reported in studies based on the assumption of first order kinetics.",

keywords = "Adolescent, Adult, Blood Glucose, C-Peptide, Humans, Insulin, Kinetics, Male, Models, Biological",

author = "B Thorsteinsson and S Fugleberg and B Feldt-Rasmussen and C Binder",

year = "1985",

month = nov,

language = "English",

volume = "57",

pages = "309--16",

journal = "Acta Pharmacologica et Toxicologica",

issn = "0001-6683",

publisher = "Munksgaard International Publishers",

number = "5",

}

### RIS

TY - JOUR

T1 - Kinetic models for plasma disappearance of insulin in normal subjects

AU - Thorsteinsson, B

AU - Fugleberg, S

AU - Feldt-Rasmussen, B

AU - Binder, C

PY - 1985/11

Y1 - 1985/11

N2 - Three theoretical kinetic models for plasma disappearance of insulin were examined in six normal men. The models allowed for the existence of non-saturable and/or saturable mechanisms. Constant infusion of porcine insulin at different rates was used to achieve different levels of steady state plasma insulin concentrations, while normoglycaemia was secured by a glucose clamp technique. Appropriate validation procedures demonstrated that one of the three models was superior to the others in describing the relationship between the exogenous insulin infusion rate Iex and the steady state plasma insulin concentration C: Iex = -Iend + k2 X C/(k3 + C), where Iend is the endogenous post-hepatic insulin delivery rate. Thus, only saturable mechanism(s) could be demonstrated. The median value of k2 (the maximal insulin disappearance rate) and k3 (the plasma insulin concentration at which the insulin disappearance rate is half maximal) were 7.31 nmol X min.-1 and 3.89 nmol X 1-1. The median value of k2/k3 (the clearance rate of insulin for infinitesimal plasma insulin concentrations) was 25.0 ml X kg-1 X min.-1. Thus, at physiological levels of plasma insulin concentrations the metabolic clearance rate of insulin is higher than insulin clearance estimates previously reported in studies based on the assumption of first order kinetics.

AB - Three theoretical kinetic models for plasma disappearance of insulin were examined in six normal men. The models allowed for the existence of non-saturable and/or saturable mechanisms. Constant infusion of porcine insulin at different rates was used to achieve different levels of steady state plasma insulin concentrations, while normoglycaemia was secured by a glucose clamp technique. Appropriate validation procedures demonstrated that one of the three models was superior to the others in describing the relationship between the exogenous insulin infusion rate Iex and the steady state plasma insulin concentration C: Iex = -Iend + k2 X C/(k3 + C), where Iend is the endogenous post-hepatic insulin delivery rate. Thus, only saturable mechanism(s) could be demonstrated. The median value of k2 (the maximal insulin disappearance rate) and k3 (the plasma insulin concentration at which the insulin disappearance rate is half maximal) were 7.31 nmol X min.-1 and 3.89 nmol X 1-1. The median value of k2/k3 (the clearance rate of insulin for infinitesimal plasma insulin concentrations) was 25.0 ml X kg-1 X min.-1. Thus, at physiological levels of plasma insulin concentrations the metabolic clearance rate of insulin is higher than insulin clearance estimates previously reported in studies based on the assumption of first order kinetics.

KW - Adolescent

KW - Adult

KW - Blood Glucose

KW - C-Peptide

KW - Humans

KW - Insulin

KW - Kinetics

KW - Male

KW - Models, Biological

M3 - Journal article

C2 - 3911734

VL - 57

SP - 309

EP - 316

JO - Acta Pharmacologica et Toxicologica

JF - Acta Pharmacologica et Toxicologica

SN - 0001-6683

IS - 5

ER -