KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

Kasper Aaboe; Filip Krag Knop; Tina Vilsbøll; Aage Vølund; Ulf Simonsen; Carolyn Fiona Deacon; Sten Madsbad; Jens Juul Holst; Thure Krarup

doi:10.1210/jc.2008-1731

KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

Kasper Aaboe, Filip Krag Knop, Tina Vilsbøll, Aage Vølund, Ulf Simonsen, Carolyn Fiona Deacon, Sten Madsbad, Jens Juul Holst, Thure Krarup

50 Citationer (Scopus)

Abstract

The reduced incretin effect in subjects with type 2 diabetes is accompanied by a severely impaired insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). The K(ATP) channels of the beta-cell appear to be essential for the function of GIP in mice, and mutations in the gene encoding these channels have been linked to the development of type 2 diabetes. With this study we therefore aimed at clarifying the role of K(ATP) channel malfunction in the impaired function of GIP.

Originalsprog	Engelsk
Tidsskrift	Journal of Clinical Endocrinology and Metabolism
Vol/bind	94
Udgave nummer	2
Sider (fra-til)	603-8
Antal sider	6
ISSN	0021-972X
DOI	https://doi.org/10.1210/jc.2008-1731
Status	Udgivet - 1 feb. 2009

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10.1210/jc.2008-1731

Citationsformater

Aaboe, K., Knop, F. K., Vilsbøll, T., Vølund, A., Simonsen, U., Deacon, C. F., Madsbad, S., Holst, J. J., & Krarup, T. (2009). KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 94(2), 603-8. https://doi.org/10.1210/jc.2008-1731

KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. / Aaboe, Kasper; Knop, Filip Krag; Vilsbøll, Tina et al.
I: Journal of Clinical Endocrinology and Metabolism, Bind 94, Nr. 2, 01.02.2009, s. 603-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Aaboe, K, Knop, FK, Vilsbøll, T, Vølund, A, Simonsen, U, Deacon, CF, Madsbad, S, Holst, JJ & Krarup, T 2009, 'KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes', Journal of Clinical Endocrinology and Metabolism, bind 94, nr. 2, s. 603-8. https://doi.org/10.1210/jc.2008-1731

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abstract = "The reduced incretin effect in subjects with type 2 diabetes is accompanied by a severely impaired insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). The K(ATP) channels of the beta-cell appear to be essential for the function of GIP in mice, and mutations in the gene encoding these channels have been linked to the development of type 2 diabetes. With this study we therefore aimed at clarifying the role of K(ATP) channel malfunction in the impaired function of GIP.",

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AU - Vølund, Aage

AU - Simonsen, Ulf

AU - Deacon, Carolyn Fiona

AU - Madsbad, Sten

AU - Holst, Jens Juul

AU - Krarup, Thure

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AB - The reduced incretin effect in subjects with type 2 diabetes is accompanied by a severely impaired insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). The K(ATP) channels of the beta-cell appear to be essential for the function of GIP in mice, and mutations in the gene encoding these channels have been linked to the development of type 2 diabetes. With this study we therefore aimed at clarifying the role of K(ATP) channel malfunction in the impaired function of GIP.

U2 - 10.1210/jc.2008-1731

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KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

Abstract

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