Abstrakt
Many autoimmune diseases like rheumatoid arthritis (RA) show gender differences. RA is triggered by an interaction between genetic, hormonal, environmental and behavioural factors. 75% of cases are women under the age of 60; lover the age 60 the gender ratio is 1:1. Different genotypes predispose for RA. Pregnancy often suppresses RA, as does oral contraception. Lactation, smoking (w), BMI > 30, heavy vibrations and certain dust particles (m) may trigger RA, while the effect of male hormones is uncertain. Future prevention should focus on environment, behavioural factors and genetic profiling.
Bidragets oversatte titel | Gender differences in autoimmune diseases illustrated by rheumatoid arthritis |
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Originalsprog | Dansk |
Tidsskrift | Ugeskrift for læger [online] |
Vol/bind | 169 |
Udgave nummer | 25 |
Sider (fra-til) | 2440-2 |
Antal sider | 3 |
ISSN | 1603-6824 |
Status | Udgivet - 18 jun. 2007 |
Emneord
- Arthritis, Rheumatoid
- Environmental Exposure
- Female
- Genetic Predisposition to Disease
- Humans
- Life Style
- Male
- Menopause
- Pregnancy
- Sex Characteristics
- Sex Factors
- Socioeconomic Factors