Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Joint Mobility and Physical Function of Danish Hemophilia Patients: A Three-Wave Panel Study Spanning 24 Years

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Myeloproliferative Neoplasms in Danish Twins

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Haemostasis and safety measures before lumbar puncture in the haematology ward: the Danish routines

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Characteristics and Long-Term Outcome of Patients with Systemic Immunoglobulin Light-Chain Amyloidosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Diagnosing von Willebrand disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Outcome of an enhanced diagnostic pipeline for patients suspected of inherited thrombocytopenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Coagulation factor VIII is vital for increasing global coagulation after physical exercise

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Work-unit social capital and long-term sickness absence: a prospective cohort study of 32 053 hospital employees

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: The positive effects of factor treatment of hemophilia are well established, but the long-term outcomes are not well documented. This panel study evaluated changes in bleeding frequency, joint mobility, physical function, and symptoms in Danish patients with moderate to severe hemophilia A or B over 24 years.

METHODS: Three anonymous surveys were conducted in 1988, 2001, and 2012 targeting Danish patients with moderate to severe hemophilia, and the study participants, respectively, were 128, 156, and 164 male patients with hemophilia (PWH). The number of bleeding episodes, the use of factor concentrate, comorbidities, joint mobility, physical function, and symptoms were evaluated by means of self-reporting. Trends over time were analyzed using ordinal and multinomial logistic-regression models controlling for age group.

RESULTS: The proportion of PWH in the oldest age group (55-88 years) increased from 4% in 1988 to 18% in 2012. In 1988, a high risk of bleeding episodes was primarily found in the age group of 16-34 years. In 2012, a high risk was primarily found in the age group of 35-54 years. Joint mobility and physical function increased significantly from 1988 to 2012 but showed a noticeable decrement in the older age groups, even in 2012. Pain in the extremities, anxiety, and depression decreased significantly, but back pain increased. No significant changes were found for 7 other symptoms.

CONCLUSIONS: Significant improvements in joint mobility and physical function have occurred over the last 24 years, but PWH > 35 years still experience a decline in these areas with age. This decline underscores the importance of life-long treatment and continuous rehabilitation of PWH.

OriginalsprogEngelsk
TidsskriftActa Haematologica
Vol/bind140
Udgave nummer4
Sider (fra-til)240-246
Antal sider7
ISSN0001-5792
DOI
StatusUdgivet - 2018

ID: 56545802