Isoniazidinduceret toksisk hepatitis

Kristina Langholz Kristensen; Anne Christine Nordholm; Mette Rye Clausen; Terese L Katzenstein

Isoniazidinduceret toksisk hepatitis

Kristina Langholz Kristensen, Anne Christine Nordholm, Mette Rye Clausen, Terese L Katzenstein

Afdeling for Infektionssygdomme

1 Citationer (Scopus)

Abstract

Hepatotoxicity is a well-known side effect to isoniazid treatment with the risk of progression to liver failure. This case report describes a 39-year-old male, who received standard isoniazid treatment for latent TB infection (LTBI) and developed severe isoniazid-induced acute hepatitis. Liver transplantation was considered, but the patient slowly recovered with full hepatic regeneration. With increasing focus on treating LTBI in Denmark, routine follow-up including biochemical monitoring should be implemented for patients receiving LTBI treatment to prevent severe complications.

Bidragets oversatte titel	Isoniazid-inducedtoxic hepatitis
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	183
Udgave nummer	6
ISSN	0041-5782
Status	Udgivet - 8 feb. 2021

Emneord

Adult
Antitubercular Agents/adverse effects
Hepatitis/drug therapy
Humans
Isoniazid/adverse effects
Latent Tuberculosis/drug therapy
Male

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Link to publication in Scopus

Citationsformater

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title = "Isoniazidinduceret toksisk hepatitis",

abstract = "Hepatotoxicity is a well-known side effect to isoniazid treatment with the risk of progression to liver failure. This case report describes a 39-year-old male, who received standard isoniazid treatment for latent TB infection (LTBI) and developed severe isoniazid-induced acute hepatitis. Liver transplantation was considered, but the patient slowly recovered with full hepatic regeneration. With increasing focus on treating LTBI in Denmark, routine follow-up including biochemical monitoring should be implemented for patients receiving LTBI treatment to prevent severe complications.",

keywords = "Adult, Antitubercular Agents/adverse effects, Hepatitis/drug therapy, Humans, Isoniazid/adverse effects, Latent Tuberculosis/drug therapy, Male",

author = "Kristensen, {Kristina Langholz} and Nordholm, {Anne Christine} and Clausen, {Mette Rye} and Katzenstein, {Terese L}",

year = "2021",

month = feb,

day = "8",

language = "Dansk",

volume = "183",

journal = "Ugeskrift for Laeger",

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publisher = "Almindelige Danske Laegeforening",

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TY - JOUR

T1 - Isoniazidinduceret toksisk hepatitis

AU - Kristensen, Kristina Langholz

AU - Nordholm, Anne Christine

AU - Clausen, Mette Rye

AU - Katzenstein, Terese L

PY - 2021/2/8

Y1 - 2021/2/8

N2 - Hepatotoxicity is a well-known side effect to isoniazid treatment with the risk of progression to liver failure. This case report describes a 39-year-old male, who received standard isoniazid treatment for latent TB infection (LTBI) and developed severe isoniazid-induced acute hepatitis. Liver transplantation was considered, but the patient slowly recovered with full hepatic regeneration. With increasing focus on treating LTBI in Denmark, routine follow-up including biochemical monitoring should be implemented for patients receiving LTBI treatment to prevent severe complications.

AB - Hepatotoxicity is a well-known side effect to isoniazid treatment with the risk of progression to liver failure. This case report describes a 39-year-old male, who received standard isoniazid treatment for latent TB infection (LTBI) and developed severe isoniazid-induced acute hepatitis. Liver transplantation was considered, but the patient slowly recovered with full hepatic regeneration. With increasing focus on treating LTBI in Denmark, routine follow-up including biochemical monitoring should be implemented for patients receiving LTBI treatment to prevent severe complications.

KW - Adult

KW - Antitubercular Agents/adverse effects

KW - Hepatitis/drug therapy

KW - Humans

KW - Isoniazid/adverse effects

KW - Latent Tuberculosis/drug therapy

KW - Male

UR - http://www.scopus.com/inward/record.url?scp=85101430361&partnerID=8YFLogxK

M3 - Tidsskriftartikel

C2 - 33570026

SN - 0041-5782

VL - 183

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 6

ER -

Isoniazidinduceret toksisk hepatitis

Abstract

Emneord

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Citationsformater