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Region Hovedstaden - en del af Københavns Universitetshospital
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Isolated Distal Deep Vein Thrombosis: Perspectives from the GARFIELD-VTE Registry

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Upper Extremity DVT versus Lower Extremity DVT: Perspectives from the GARFIELD-VTE Registry

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Characteristics and Management of Patients with Venous Thromboembolism: The GARFIELD-VTE Registry

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Smoking is Associated with Increased Risk of Major Bleeding: A Prospective Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Assessment of Outcomes Among Patients With Venous Thromboembolism With and Without Chronic Kidney Disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Comparative effectiveness of oral anticoagulants in venous thromboembolism: GARFIELD-VTE

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Anticoagulation therapy patterns for acute treatment of venous thromboembolism in GARFIELD-VTE patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Upper Extremity DVT versus Lower Extremity DVT: Perspectives from the GARFIELD-VTE Registry

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Sebastian M Schellong
  • Samuel Z Goldhaber
  • Jeffrey I Weitz
  • Walter Ageno
  • Henri Bounameaux
  • Alexander G G Turpie
  • Pantep Angchaisuksiri
  • Sylvia Haas
  • Shinya Goto
  • Audrey Zaghdoun
  • Alfredo Farjat
  • Joern Dalsgaard Nielsen
  • Gloria Kayani
  • Lorenzo G Mantovani
  • Paolo Prandoni
  • Ajay K Kakkar
Vis graf over relationer

Isolated distal deep vein thrombosis (IDDVT) represents up to half of all lower limb DVT. This study investigated treatment patterns and outcomes in 2,145 patients with IDDVT in comparison with those with proximal DVT (PDVT; n = 3,846) and pulmonary embolism (PE; n = 4,097) enrolled in the GARFIELD-VTE registry. IDDVT patients were more likely to have recently undergone surgery (14.6%) or experienced leg trauma (13.2%) than PDVT patients (11.0 and 8.7%, respectively) and PE patients (12.7 and 4.5%, respectively). Compared with IDDVT, patients with PDVT or PE were more likely to have active cancer (7.2% vs. 9.9% and 10.3%). However, influence of provoking factors on risk of recurrence in IDDVT remains controversial. Nearly all patients (IDDVT, PDVT, and PE) were given anticoagulant therapy. In IDDVT, PDVT, and PE groups the proportion of patients receiving anticoagulant therapy was 61.4, 73.9, and 81.1% at 6 months and 45.8, 54.7, and 61.9% at 12 months. Over 12 months, the incidence of all-cause mortality, cancer, and recurrence was significantly lower in IDDVT patients than PDVT patients (hazard ratio [HR], 0.61 [95% confidence interval [CI], 0.48-0.77]; sub-HR [sHR], 0.60 [95% CI, 0.39-0.93]; and sHR, 0.76 [95% CI, 0.60-0.97]). Likewise, risk of death and incident cancer was significantly (both p < 0.05) lower in patients with IDDVT compared with PE. This study reveals a global trend that most IDDVT patients as well as those with PDVT and PE are given anticoagulant therapy, in many cases for at least 12 months.

OriginalsprogEngelsk
TidsskriftThrombosis and Haemostasis
Vol/bind119
Udgave nummer10
Sider (fra-til)1675-1685
Antal sider11
ISSN0340-6245
DOI
StatusUdgivet - okt. 2019

Bibliografisk note

Georg Thieme Verlag KG Stuttgart · New York.

ID: 61882387