Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study

Frederik Faergemann Lau, Signe Bollerup, Frederik Engsig, Henrik Krarup, Lone Hagens Mygind, Jesper Bach Hansen, Lone Galmstrup Madsen, Peter Thielsen, Ulla Balslev, Lars Nørregaard Nielsen, Toke S Barfod, Mette Rye Clausen, Lise Hobolth, Alex Lund Laursen, Britta Tarp, Birgit T Roege, Jan Gerstoft, Peer Brehm Christensen, Nina Weis*

*Corresponding author af dette arbejde


Objective: Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population.

Study Design and Setting: We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model.

Results: In total, 6472 persons with CHB and 62,251 age- and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59%) with CHB and 1058 (1,70%) control-persons developed IHD. The crude IRR was 1.13 (95% CI: 0.91-1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95% CI: 0.76-1.21).

Conclusion: In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.

TidsskriftClinical Epidemiology
Sider (fra-til)879-888
Antal sider10
StatusUdgivet - 2022


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