TY - JOUR
T1 - Is there an inherent limit to the efficacy of calcitonin gene-related peptide receptor antagonists in the acute treatment of migraine? A comment
AU - Tfelt-Hansen, Peer C
N1 - Keywords: Azepines; Calcitonin Gene-Related Peptide; Cerebral Arteries; Clinical Trials as Topic; Dipeptides; Humans; Imidazoles; Migraine Disorders; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Serotonin Agonists; Treatment Failure; Tryptamines
PY - 2009
Y1 - 2009
N2 - Calcitonin gene-related peptide (CGRP) receptor antagonists are a new treatment principle in acute migraine attacks. Intravenous olcegepant 2.5 mg resulted in 66% headache relief after 2 h, whereas subcutaneous sumatriptan resulted in 81-92% headache relief after 2 h. The intrinsic activity of a parenteral triptan, a 5HT(1B/1D) receptor agonist, is thus higher than the maximum effect of the parenteral CGRP receptor antagonist olcegepant. For the orally bioavailable CGRP antagonist telcagepant 300 mg, the headache relief was only 55% in one phase III study. These results indicate that CGRP receptor antagonism results in success in the acute treatment of migraine in only a certain fraction of the patients.
AB - Calcitonin gene-related peptide (CGRP) receptor antagonists are a new treatment principle in acute migraine attacks. Intravenous olcegepant 2.5 mg resulted in 66% headache relief after 2 h, whereas subcutaneous sumatriptan resulted in 81-92% headache relief after 2 h. The intrinsic activity of a parenteral triptan, a 5HT(1B/1D) receptor agonist, is thus higher than the maximum effect of the parenteral CGRP receptor antagonist olcegepant. For the orally bioavailable CGRP antagonist telcagepant 300 mg, the headache relief was only 55% in one phase III study. These results indicate that CGRP receptor antagonism results in success in the acute treatment of migraine in only a certain fraction of the patients.
U2 - 10.1007/s10194-009-0157-8
DO - 10.1007/s10194-009-0157-8
M3 - Editorial
C2 - 19779958
SN - 1129-2369
VL - 10
SP - 389
EP - 391
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
IS - 6
ER -