Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Is there a correlation between androgens and sexual desire in women?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Female Orgasm and Overall Sexual Function and Habits: A Descriptive Study of a Cohort of U.S. Women

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Contemporary Thoughts on the Role of Shockwave Therapy in Peyronie's Disease

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  3. YouTube as a Source of Information About Premature Ejaculation Treatment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Kirurgisk behandling ved kvindelig infertilitet

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Preserved postprandial suppression of bone turnover markers, despite increased fasting levels, in postmenopausal women

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

INTRODUCTION: For women, the correlation between circulating androgens and sexual desire is inconclusive. Substitution with androgens at physiological levels improves sexual function in women who experience decreased sexual desire and androgen deficiency from surgical menopause, pituitary disease, and age-related decline in androgen production in the ovaries. Measuring bioactive testosterone is difficult and new methods have been proposed, including measuring the primary androgen metabolite androsterone glucuronide (ADT-G).

AIM: The aim of this study was to investigate a possible correlation between serum levels of androgens and sexual desire in women and whether the level of ADT-G is better correlated than the level of circulating androgens with sexual desire.

METHODS: This was a cross-sectional study including 560 healthy women aged 19-65 years divided into three age groups. Correlations were considered to be statistically significant at P < 0.05.

MAIN OUTCOME MEASURE: Sexual desire was determined as the total score of the sexual desire domain of the Female Sexual Function Index. Total testosterone (TT), calculated free testosterone (FT), androstenedione, dehydroepiandrosterone sulfate (DHEAS), and ADT-G were analyzed using mass spectrometry.

RESULTS: Sexual desire correlated overall with FT and androstenedione in the total cohort of women. In a subgroup of women aged 25-44 years with no use of systemic hormonal contraception, sexual desire correlated with TT, FT, androstenedione, and DHEAS. In women aged 45-65 years, androstenedione correlated with sexual desire. No correlations between ADT-G and sexual desire were identified.

CONCLUSIONS: In the present study, FT and androstenedione were statistically significantly correlated with sexual desire in the total cohort of women. ADT-G did not correlate more strongly than circulating androgens with sexual desire and is therefore not superior to measuring circulating androgens by mass spectrometry. Wåhlin-Jacobsen S, Pedersen AT, Kristensen E, Laessøe NC, Lundqvist M, Cohen AS, Hougaard DM, and Giraldi A. Is there a correlation between androgens and sexual desire in women? J Sex Med 2015;12:358-373.

OriginalsprogEngelsk
TidsskriftThe journal of sexual medicine
Vol/bind12
Udgave nummer2
Sider (fra-til)358-73
Antal sider16
ISSN1743-6095
DOI
StatusUdgivet - feb. 2015

ID: 45055280