Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Is the thin layer of methyl aminolevulinate used during photodynamic therapy sufficient?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Photoprotection by sunscreen depends on time spent on application

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Factors associated with cessation of sunbed use among Danish women

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Short-term chemical pretreatment cannot replace curettage in photodynamic therapy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Daylight PDT acts by continuous activation of PpIX

    Publikation: Bidrag til tidsskriftLederForskningpeer review

Vis graf over relationer

BACKGROUND: If the recommended 1.0 mm layer of methyl aminolevulinate (MAL) is used during photodynamic therapy (PDT) of large areas with multiple actinic keratoses (AK) huge amounts of cream are needed.

OBJECTIVES: To report the amount of MAL used for PDT of AK and basal cell carcinomas (BCC) in daily routine. The association of protoporphyrin IX (PpIX) fluorescence and thickness of MAL was investigated in a randomized paired study in healthy volunteers.

METHODS: Amount of cream used per cm(2) during conventional and daylight PDT was recorded. In 16 healthy volunteers, 0.1 mm, 0.2 mm, 0.5 mm and 1.0 mm MAL cream were applied for 3 h on tape-stripped areas on each forearm randomized to light-permeable or light-impermeable occlusion. PpIX fluorescence was measured.

RESULTS: Less than 0.4 mm MAL was used during PDT of BCC and 0.2 mm for AK. No difference in PpIX fluorescence was found between the different thicknesses of MAL using light-impermeable occlusion.

CONCLUSION: In daily routine <0.4 mm MAL was used during PDT of BCC and 0.1-0.2 mm MAL during PDT of AK. The recommended 1.0 mm MAL did not result in a higher accumulation of PpIX compared to thinner MAL layers after light-impermeable occlusion for 3 h.

OriginalsprogEngelsk
TidsskriftPhotodermatology, Photoimmunology & Photomedicine
Vol/bind32
Udgave nummer2
Sider (fra-til)88-92
Antal sider5
ISSN0905-4383
DOI
StatusUdgivet - mar. 2016

ID: 49585779