Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?

Maiken Thyregod Jøergensen; Klaus Brusgaard; Srdan Novovic; Anders Møller Andersen; Mark Berner Hansen; Anne-Marie Gerdes; Ove Bent Schaffalitzky de Muckadell

doi:10.1097/MEG.0b013e32834ee5e2

Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?

Maiken Thyregod Jøergensen, Klaus Brusgaard, Srdan Novovic, Anders Møller Andersen, Mark Berner Hansen, Anne-Marie Gerdes, Ove Bent Schaffalitzky de Muckadell

7 Citationer (Scopus)

Abstract

Serine Protease Inhibitor Kazal type 1 (SPINK1) protects against premature intracellular activation of trypsinogen and development of acute pancreatitis. Our aim was to determine the prevalence of SPINK1 mutations (a) in unselected patients with first-time acute pancreatitis and (b) in the Danish background population (c) in a meta-analysis to combine the results with findings in similar investigations worldwide and (d) to evaluate whether patients with SPINK1 mutations had a more severe clinical course.

Originalsprog	Engelsk
Tidsskrift	European Journal of Gastroenterology and Hepatology
Vol/bind	24
Udgave nummer	3
Sider (fra-til)	309-15
Antal sider	7
ISSN	0954-691X
DOI	https://doi.org/10.1097/MEG.0b013e32834ee5e2
Status	Udgivet - 2012

Adgang til dokumentet

10.1097/MEG.0b013e32834ee5e2

Citationsformater

@article{606b717ee2e84b878db1bbe9345819d0,

title = "Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?",

abstract = "Serine Protease Inhibitor Kazal type 1 (SPINK1) protects against premature intracellular activation of trypsinogen and development of acute pancreatitis. Our aim was to determine the prevalence of SPINK1 mutations (a) in unselected patients with first-time acute pancreatitis and (b) in the Danish background population (c) in a meta-analysis to combine the results with findings in similar investigations worldwide and (d) to evaluate whether patients with SPINK1 mutations had a more severe clinical course.",

keywords = "Acute Disease, Aged, Biological Markers, C-Reactive Protein, Carrier Proteins, Case-Control Studies, Denmark, Female, Humans, Male, Middle Aged, Mutation, Pancreatitis, Prognosis, Prospective Studies",

author = "J{\o}ergensen, {Maiken Thyregod} and Klaus Brusgaard and Srdan Novovic and Andersen, {Anders M{\o}ller} and Hansen, {Mark Berner} and Anne-Marie Gerdes and {de Muckadell}, {Ove Bent Schaffalitzky}",

note = "Author(s): Joergensen, MT (Joergensen, Maiken Thyregod)[ 1 ] ; Brusgaard, K (Brusgaard, Klaus)[ 2 ] ; Novovic, S (Novovic, Srdan)[ 4 ] ; Andersen, AM (Andersen, Anders Moller)[ 4 ] ; Hansen, MB (Hansen, Mark Berner)[ 4,5 ] ; Gerdes, AM (Gerdes, Anne-Marie)[ 2,3 ] ; de Muckadell, OBS (de Muckadell, Ove Bent Schaffalitzky)[ 1 ] 1 ] Univ So Denmark, Dept Med Gastroenterol S, Odense Univ Hosp, DK-5000 Odense C, Denmark [ 2 ] Univ So Denmark, Dept Clin Genet, Odense Univ Hosp, DK-5000 Odense C, Denmark [ 3 ] Univ Copenhagen, Rigshosp, Dept Clin Genet, DK-2100 Copenhagen, Denmark [ 4 ] Univ Copenhagen, Bispebjerg Hosp, Dept Surg K, Copenhagen, Denmark [ 5 ] AstraZeneca Res & Dev, Molndal, Sweden",

year = "2012",

doi = "10.1097/MEG.0b013e32834ee5e2",

language = "English",

volume = "24",

pages = "309--15",

journal = "European Journal of Gastroenterology and Hepatology",

issn = "0954-691X",