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Is the Association Between Parents’ Mental Illness and Child Psychopathology Mediated via Home Environment and Caregiver’s Psychosocial Functioning? A Mediation Analysis of the Danish High Risk and Resilience Study—VIA7, a Population-Based Cohort Study

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@article{6f027534b86f41c7abe686765428372c,
title = "Is the Association Between Parents{\textquoteright} Mental Illness and Child Psychopathology Mediated via Home Environment and Caregiver{\textquoteright}s Psychosocial Functioning?: A Mediation Analysis of the Danish High Risk and Resilience Study—VIA7, a Population-Based Cohort Study",
abstract = "We aimed to investigate to which degree the home environment and/or primary caregivers{\textquoteright} level of functioning mediate the association between parental mental illness (eg, schizophrenia) and child psychopathology. We used data from the nationwide Danish High Risk and Resilience Study—VIA7. The study sample comprised 522 seven-year-old children. The main outcome was the child psychopathology, assessed with the Child Behavior Checklist (CBCL). The exposure variable had 3 categories: children at familial high risk of schizophrenia spectrum psychosis (FHR-SZ), bipolar disorder (FHR-BP), and population-based controls. Mediators were quality of the Home Observation for Measurement of the Environment (HOME) and primary caregiver{\textquoteright}s Personal and Social Performance Scale (primary caregiver functioning). Primary caregiver{\textquoteright}s IQ and polygenic risk scores (PRS) for the educational attainment of the children were considered as covariates. We found a significant indirect adjusted effect of FHR status vs controls on CBCL total scores (FHR-SZ = 5.34, 95% confidence interval [CI]: 3.50–7.47 and FHR-BP = 4.54, 95% CI: 2.65–6.68), through primary caregiver functioning and HOME. Both mediators combined explained 53% and 64% variation of the total effects of FHR-SZ and FHR-BP, respectively. Adjusting for the PRS in the mediation models only resulted in minor changes in the FHR effects on the CBCL. We conclude that the HOME and the primary caregiver functioning are important mediating factors for child psychopathology, especially in children born with familial risk for severe mental illness. This knowledge may represent a window of opportunity for the development of preventive strategies (eg, intervention to improve primary caregiver functioning and home environment).",
author = "Uddin, {Md Jamal} and Ekstr{\o}m, {Claus Thorn} and Nicoline Hemager and Christiani, {Camilla Jerlang} and Maja Gregersen and Ellersgaard, {Ditte Vestbjerg} and Spang, {Katrine S{\o}borg} and Aja Greve and Gantriis, {Ditte Lou Langhoff} and Burton, {Hanne Birgitte Klee} and Anne S{\o}ndergaard and Ron Nudel and {Bo Mortensen}, Preben and Pedersen, {Marianne Gi{\o}rtz} and {B{\o}cker Pedersen}, Carsten and Yunpeng Wang and Werge, {Thomas Mears} and Jonas Bybjerg-Grauholm and Plessen, {Kerstin J} and Vibeke Bliksted and Ole Mors and Thorup, {Anne Amalie Elgaard} and Merete Nordentoft",
year = "2021",
month = jun,
day = "26",
doi = "10.1093/schizbullopen/sgab024",
language = "Dansk",
volume = "2",
journal = "Schizophrenia Bulletin Open",
issn = "2632-7899",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Is the Association Between Parents’ Mental Illness and Child Psychopathology Mediated via Home Environment and Caregiver’s Psychosocial Functioning?

T2 - A Mediation Analysis of the Danish High Risk and Resilience Study—VIA7, a Population-Based Cohort Study

AU - Uddin, Md Jamal

AU - Ekstrøm, Claus Thorn

AU - Hemager, Nicoline

AU - Christiani, Camilla Jerlang

AU - Gregersen, Maja

AU - Ellersgaard, Ditte Vestbjerg

AU - Spang, Katrine Søborg

AU - Greve, Aja

AU - Gantriis, Ditte Lou Langhoff

AU - Burton, Hanne Birgitte Klee

AU - Søndergaard, Anne

AU - Nudel, Ron

AU - Bo Mortensen, Preben

AU - Pedersen, Marianne Giørtz

AU - Bøcker Pedersen, Carsten

AU - Wang, Yunpeng

AU - Werge, Thomas Mears

AU - Bybjerg-Grauholm, Jonas

AU - Plessen , Kerstin J

AU - Bliksted, Vibeke

AU - Mors, Ole

AU - Thorup, Anne Amalie Elgaard

AU - Nordentoft, Merete

PY - 2021/6/26

Y1 - 2021/6/26

N2 - We aimed to investigate to which degree the home environment and/or primary caregivers’ level of functioning mediate the association between parental mental illness (eg, schizophrenia) and child psychopathology. We used data from the nationwide Danish High Risk and Resilience Study—VIA7. The study sample comprised 522 seven-year-old children. The main outcome was the child psychopathology, assessed with the Child Behavior Checklist (CBCL). The exposure variable had 3 categories: children at familial high risk of schizophrenia spectrum psychosis (FHR-SZ), bipolar disorder (FHR-BP), and population-based controls. Mediators were quality of the Home Observation for Measurement of the Environment (HOME) and primary caregiver’s Personal and Social Performance Scale (primary caregiver functioning). Primary caregiver’s IQ and polygenic risk scores (PRS) for the educational attainment of the children were considered as covariates. We found a significant indirect adjusted effect of FHR status vs controls on CBCL total scores (FHR-SZ = 5.34, 95% confidence interval [CI]: 3.50–7.47 and FHR-BP = 4.54, 95% CI: 2.65–6.68), through primary caregiver functioning and HOME. Both mediators combined explained 53% and 64% variation of the total effects of FHR-SZ and FHR-BP, respectively. Adjusting for the PRS in the mediation models only resulted in minor changes in the FHR effects on the CBCL. We conclude that the HOME and the primary caregiver functioning are important mediating factors for child psychopathology, especially in children born with familial risk for severe mental illness. This knowledge may represent a window of opportunity for the development of preventive strategies (eg, intervention to improve primary caregiver functioning and home environment).

AB - We aimed to investigate to which degree the home environment and/or primary caregivers’ level of functioning mediate the association between parental mental illness (eg, schizophrenia) and child psychopathology. We used data from the nationwide Danish High Risk and Resilience Study—VIA7. The study sample comprised 522 seven-year-old children. The main outcome was the child psychopathology, assessed with the Child Behavior Checklist (CBCL). The exposure variable had 3 categories: children at familial high risk of schizophrenia spectrum psychosis (FHR-SZ), bipolar disorder (FHR-BP), and population-based controls. Mediators were quality of the Home Observation for Measurement of the Environment (HOME) and primary caregiver’s Personal and Social Performance Scale (primary caregiver functioning). Primary caregiver’s IQ and polygenic risk scores (PRS) for the educational attainment of the children were considered as covariates. We found a significant indirect adjusted effect of FHR status vs controls on CBCL total scores (FHR-SZ = 5.34, 95% confidence interval [CI]: 3.50–7.47 and FHR-BP = 4.54, 95% CI: 2.65–6.68), through primary caregiver functioning and HOME. Both mediators combined explained 53% and 64% variation of the total effects of FHR-SZ and FHR-BP, respectively. Adjusting for the PRS in the mediation models only resulted in minor changes in the FHR effects on the CBCL. We conclude that the HOME and the primary caregiver functioning are important mediating factors for child psychopathology, especially in children born with familial risk for severe mental illness. This knowledge may represent a window of opportunity for the development of preventive strategies (eg, intervention to improve primary caregiver functioning and home environment).

U2 - 10.1093/schizbullopen/sgab024

DO - 10.1093/schizbullopen/sgab024

M3 - Tidsskriftartikel

VL - 2

JO - Schizophrenia Bulletin Open

JF - Schizophrenia Bulletin Open

SN - 2632-7899

IS - 1

ER -

ID: 67383850