Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Is smoking heaviness causally associated with alcohol use? A Mendelian randomization study in four European cohorts

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Long-term risk of tuberculosis among migrants according to migrant status: a cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cohort profile: Effective Perinatal Intensive Care in Europe (EPICE) very preterm birth cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cohort Profile: The Copenhagen Child Cohort Study (CCC2000)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Appraising the causal relevance of DNA methylation for risk of lung cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Cardiac chamber volumes and left ventricular mass in people living with HIV and matched uninfected controls

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Interstitial lung abnormalities in people with HIV infection and uninfected controls

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Background: Observational studies have shown that tobacco and alcohol use co-occur, but it is not clear whether this relationship is causal.

Methods: Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) and UK Biobank, we used observational methods to test the hypothesis that smoking heaviness increases alcohol consumption. Mendelian randomization (MR) analyses were then used to test the causal relationship between smoking heaviness and alcohol consumption using 55 967 smokers from four European studies [ALSPAC, The Nord-Trøndelag Health Study (HUNT), the Copenhagen General Population Study (CGPS) and UK Biobank]. MR analyses used rs1051730/rs16969968 as a genetic proxy for smoking heaviness.

Results: Observational results provided evidence of an association between cigarettes per day and weekly alcohol consumption (increase in units of alcohol per additional cigarette smoked per day = 0.10, 95% confidence interval (CI) 0.05 to 0.15, P ≤ 0.001 in ALSPAC; and 0.48, 95% CI 0.45 to 0.52, P ≤ 0.001 in UK Biobank). However, there was little evidence for an association between rs1051730/rs16969968 and units of alcohol consumed per week across ALSPAC, HUNT, CGPS and UK Biobank (standard deviation increase in units of alcohol per additional copy of the risk allele = -0.004, 95% CI -0.023 to 0.016, P=0.708, I2 = 51.9%). We had 99% and 88% power to detect a change of 0.03 and 0.02 standard deviation units of alcohol per additional copy of the risk allele, respectively.

Conclusions: Previously reported associations between smoking and alcohol are unlikely to be causal, and may be the result of confounding and/or reverse causation. This has implications for public health research and intervention research.

OriginalsprogEngelsk
TidsskriftInternational Journal of Epidemiology
Vol/bind47
Udgave nummer4
Sider (fra-til)1098-1105
Antal sider8
ISSN0300-5771
DOI
StatusUdgivet - 1 aug. 2018

ID: 56617391