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Irritable bowel syndrome, the microbiota and the gut-brain axis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Irritable bowel syndrome is a common functional gastrointestinal disorder and it is now evident that irritable bowel syndrome is a multi-factorial complex of changes in microbiota and immunology. The bidirectional neurohumoral integrated communication between the microbiota and the autonomous nervous system is called the gut-brain-axis, which integrates brain and GI functions, such as gut motility, appetite and weight. The gut-brain-axis has a central function in the perpetuation of irritable bowel syndrome and the microbiota plays a critical role. The purpose of this article is to review recent research concerning the epidemiology of irritable bowel syndrome, influence of microbiota, probiota, gut-brain-axis, and possible treatment modalities on irritable bowel syndrome.

OriginalsprogEngelsk
TidsskriftGut Microbes
Vol/bind7
Udgave nummer5
Sider (fra-til)365-383
ISSN1949-0976
DOI
StatusUdgivet - okt. 2016

ID: 48333721