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IP-10 release assays in the diagnosis of tuberculosis infection: current status and future directions

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@article{570ee96dcf08484fb7f3b2a2af6f01ec,
title = "IP-10 release assays in the diagnosis of tuberculosis infection: current status and future directions",
abstract = "The current state-of-the-art tests for infection with Mycobacterium tuberculosis - the IFN-γ release assays - rely on accurate measurement of the cytokine IFN-γ. Many other potential biomarkers are expressed in concert with IFN-γ, and IP-10 in particular has shown promising results. IP-10 is produced in large amounts, allowing for the development of new and simplified test platforms, such as lateral flow. In this review, we summarize the results of 22 clinical studies exploring the use of IP-10 as an alternative marker to IFN-γ. The studies report that diagnostic accuracy of IP-10 is on par with IFN-γ, but also that IP-10 may be more robust in young children and in HIV-infected individuals with low CD4 cell counts. We conclude the review by presenting limitations of the published works and outline recent developments and future directions.",
keywords = "Biological Markers, Case-Control Studies, Chemokine CXCL10, Coinfection, HIV Infections, Humans, Interferon-gamma, Mycobacterium tuberculosis, Reagent Kits, Diagnostic, Tuberculosis, Pulmonary",
author = "Morten Ruhwald and Aabye, {Martine G} and Pernille Ravn",
year = "2012",
doi = "10.1586/erm.11.97",
language = "English",
volume = "12",
pages = "175--87",
journal = "Expert Review of Molecular Diagnostics",
issn = "1473-7159",
publisher = "Expert Reviews Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - IP-10 release assays in the diagnosis of tuberculosis infection

T2 - current status and future directions

AU - Ruhwald, Morten

AU - Aabye, Martine G

AU - Ravn, Pernille

PY - 2012

Y1 - 2012

N2 - The current state-of-the-art tests for infection with Mycobacterium tuberculosis - the IFN-γ release assays - rely on accurate measurement of the cytokine IFN-γ. Many other potential biomarkers are expressed in concert with IFN-γ, and IP-10 in particular has shown promising results. IP-10 is produced in large amounts, allowing for the development of new and simplified test platforms, such as lateral flow. In this review, we summarize the results of 22 clinical studies exploring the use of IP-10 as an alternative marker to IFN-γ. The studies report that diagnostic accuracy of IP-10 is on par with IFN-γ, but also that IP-10 may be more robust in young children and in HIV-infected individuals with low CD4 cell counts. We conclude the review by presenting limitations of the published works and outline recent developments and future directions.

AB - The current state-of-the-art tests for infection with Mycobacterium tuberculosis - the IFN-γ release assays - rely on accurate measurement of the cytokine IFN-γ. Many other potential biomarkers are expressed in concert with IFN-γ, and IP-10 in particular has shown promising results. IP-10 is produced in large amounts, allowing for the development of new and simplified test platforms, such as lateral flow. In this review, we summarize the results of 22 clinical studies exploring the use of IP-10 as an alternative marker to IFN-γ. The studies report that diagnostic accuracy of IP-10 is on par with IFN-γ, but also that IP-10 may be more robust in young children and in HIV-infected individuals with low CD4 cell counts. We conclude the review by presenting limitations of the published works and outline recent developments and future directions.

KW - Biological Markers

KW - Case-Control Studies

KW - Chemokine CXCL10

KW - Coinfection

KW - HIV Infections

KW - Humans

KW - Interferon-gamma

KW - Mycobacterium tuberculosis

KW - Reagent Kits, Diagnostic

KW - Tuberculosis, Pulmonary

U2 - 10.1586/erm.11.97

DO - 10.1586/erm.11.97

M3 - Journal article

VL - 12

SP - 175

EP - 187

JO - Expert Review of Molecular Diagnostics

JF - Expert Review of Molecular Diagnostics

SN - 1473-7159

IS - 2

ER -

ID: 34909909