TY - JOUR
T1 - IP-10 Can Be Measured in Dried Plasma Spots in Patients with Chronic Hepatitis C Infection
AU - Ruhwald, Morten
AU - Andersen, Ellen Sloth
AU - Christensen, Peer Brehm
AU - Moessner, Belinda Klemmensen
AU - Weis, Nina
PY - 2012
Y1 - 2012
N2 - The chemokine IP-10 (CXCL10) is a candidate marker for hepatitis C virus (HCV) fibrosis monitoring. The aim of this proof-of-concept study is to assess if IP-10 measurements from dried plasma spots (DPS) are accurate in HCV-infected patients with either minimal or significant fibrosis. We measured IP-10 levels in plasma and DPS of 21 HCV-infected patients with cirrhosis and 19 patients with no/little fibrosis (determined with FibroScan). Cirrhotic patients had significantly higher levels of IP-10 compared to patients with minimal fibrosis. DPS and plasma measurements of IP-10 are comparable and the correlation was excellent (r(2) = 0.97, p
AB - The chemokine IP-10 (CXCL10) is a candidate marker for hepatitis C virus (HCV) fibrosis monitoring. The aim of this proof-of-concept study is to assess if IP-10 measurements from dried plasma spots (DPS) are accurate in HCV-infected patients with either minimal or significant fibrosis. We measured IP-10 levels in plasma and DPS of 21 HCV-infected patients with cirrhosis and 19 patients with no/little fibrosis (determined with FibroScan). Cirrhotic patients had significantly higher levels of IP-10 compared to patients with minimal fibrosis. DPS and plasma measurements of IP-10 are comparable and the correlation was excellent (r(2) = 0.97, p
U2 - 10.1371/journal.pone.0045181
DO - 10.1371/journal.pone.0045181
M3 - Journal article
C2 - 23024806
SN - 1932-6203
VL - 7
SP - e45181
JO - P L o S One
JF - P L o S One
IS - 9
ER -