Iodine deficiency in pregnancy is prevalent in vulnerable groups in Denmark

Ditte Marie Kirkegaard-Klitbo, Kathrine Perslev, Stine Linding Andersen, Hans Perrild, Nils Knudsen, Tom Weber, Lone Banke Rasmussen, Peter Laurberg

20 Citationer (Scopus)

Abstract

INTRODUCTION: Iodine is essential for the production of thyroid hormones. In pregnancy, physiological changes occur that can lead to iodine deficiency and impairment of fetal neurological development. We aimed to assess the iodine intake in pregnant women in Eastern Denmark, compare iodine levels in Eastern and Western Denmark and to identify potentially vulnerable groups.

METHODS: This was a cross-sectional cohort study of pregnant Danish women (n = 240). Questionnaires and urine samples were collected at the Ultrasound Clinic, Hvidovre Hospital, Denmark, and urinary iodine concentrations (UIC) (µg/l) were measured. Predictors of iodine supplement use were examined by multivariate logistic regression models.

RESULTS: The pregnant women from Eastern Denmark had a median age of 30 years and the median gestational week at which they were included in the study was week 19. The majority took iodine-containing supplements (86%). The median UIC was 118 (interquartile range (IQR): 79-196) µg/l in iodine supplement users and 82 (IQR: 41-122) µg/l in non-users (p < 0.001). Predictors of not using iodine supplement in Eastern and Western Denmark were short maternal education, non-Danish origin and pre-pregnancy obesity.

CONCLUSIONS: The iodine status in Danish pregnant women was below WHO recommendations. Iodine supplement non-users are at a particular risk of iodine deficiency. Low maternal education, non-Danish origin and pre-pregnancy obesity are predictors of non-iodine supplement use. An increase in iodine fortification may be recommended to improve the iodine status in pregnant Danish women.

FUNDING: none.

TRIAL REGISTRATION: not relevant.

OriginalsprogEngelsk
TidsskriftDanish Medical Bulletin (Online)
Vol/bind63
Udgave nummer11
Sider (fra-til)A5286
Antal sider5
ISSN1603-9629
StatusUdgivet - nov. 2016

Fingeraftryk

Dyk ned i forskningsemnerne om 'Iodine deficiency in pregnancy is prevalent in vulnerable groups in Denmark'. Sammen danner de et unikt fingeraftryk.

Citationsformater