Investigations in children who were in utero at onset of insulin-dependent diabetes in their mothers

K Buschard; C Kühl; L Mølsted-Pedersen; E Lund; J Palmer; G F Bottazzo

doi:10.1016/s0140-6736(89)92272-1

Investigations in children who were in utero at onset of insulin-dependent diabetes in their mothers

K Buschard
, C Kühl
, L Mølsted-Pedersen
, E Lund
, J Palmer
, G F Bottazzo

7 Citationer (Scopus)

Abstract

55 children who were in utero when type 1 diabetes developed in their mothers were studied at a mean (SEM) age of 10.4 (0.6) years: only 1 was diabetic. Biochemical and immunological indices, measured in 35 children, showed no evidence of beta cell dysfunction. Thus, the fetal beta cells seem to be unaffected by the mechanisms that cause diabetes in their mothers.

Originalsprog	Engelsk
Tidsskrift	Lancet
Vol/bind	1
Udgave nummer	8642
Sider (fra-til)	811-4
Antal sider	4
ISSN	0140-6736
DOI	https://doi.org/10.1016/s0140-6736(89)92272-1
Status	Udgivet - 15 apr. 1989
Udgivet eksternt	Ja

Adgang til dokumentet

10.1016/s0140-6736(89)92272-1

Citationsformater

@article{99daf5ec14cc42a18968e82571434d13,

title = "Investigations in children who were in utero at onset of insulin-dependent diabetes in their mothers",

abstract = "55 children who were in utero when type 1 diabetes developed in their mothers were studied at a mean (SEM) age of 10.4 (0.6) years: only 1 was diabetic. Biochemical and immunological indices, measured in 35 children, showed no evidence of beta cell dysfunction. Thus, the fetal beta cells seem to be unaffected by the mechanisms that cause diabetes in their mothers.",

keywords = "Adolescent, Adult, Antibodies/analysis, Autoantibodies/analysis, Child, Child, Preschool, Cohort Studies, Denmark, Diabetes Mellitus, Type 1/drug therapy, Female, Fetus, Follow-Up Studies, Humans, Immunoglobulin G/analysis, Insulin/immunology, Islets of Langerhans/immunology, Pancreas/cytology, Pregnancy, Pregnancy in Diabetics/drug therapy, Prognosis",

author = "K Buschard and C K{\"u}hl and L M{\o}lsted-Pedersen and E Lund and J Palmer and Bottazzo, \{G F\}",

year = "1989",

month = apr,

day = "15",

doi = "10.1016/s0140-6736(89)92272-1",

language = "English",

volume = "1",

pages = "811--4",

journal = "Lancet",

issn = "0140-6736",

publisher = "Elsevier BV",

number = "8642",

}

TY - JOUR

T1 - Investigations in children who were in utero at onset of insulin-dependent diabetes in their mothers

AU - Buschard, K

AU - Kühl, C

AU - Mølsted-Pedersen, L

AU - Lund, E

AU - Palmer, J

AU - Bottazzo, G F

PY - 1989/4/15

Y1 - 1989/4/15

N2 - 55 children who were in utero when type 1 diabetes developed in their mothers were studied at a mean (SEM) age of 10.4 (0.6) years: only 1 was diabetic. Biochemical and immunological indices, measured in 35 children, showed no evidence of beta cell dysfunction. Thus, the fetal beta cells seem to be unaffected by the mechanisms that cause diabetes in their mothers.

AB - 55 children who were in utero when type 1 diabetes developed in their mothers were studied at a mean (SEM) age of 10.4 (0.6) years: only 1 was diabetic. Biochemical and immunological indices, measured in 35 children, showed no evidence of beta cell dysfunction. Thus, the fetal beta cells seem to be unaffected by the mechanisms that cause diabetes in their mothers.

KW - Adolescent

KW - Adult

KW - Antibodies/analysis

KW - Autoantibodies/analysis

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Denmark

KW - Diabetes Mellitus, Type 1/drug therapy

KW - Female

KW - Fetus

KW - Follow-Up Studies

KW - Humans

KW - Immunoglobulin G/analysis

KW - Insulin/immunology

KW - Islets of Langerhans/immunology

KW - Pancreas/cytology

KW - Pregnancy

KW - Pregnancy in Diabetics/drug therapy

KW - Prognosis

U2 - 10.1016/s0140-6736(89)92272-1

DO - 10.1016/s0140-6736(89)92272-1

M3 - Journal article

C2 - 2564904

SN - 0140-6736

VL - 1

SP - 811

EP - 814

JO - Lancet

JF - Lancet

IS - 8642

ER -

Investigations in children who were in utero at onset of insulin-dependent diabetes in their mothers

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater