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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Investigation of hydrogen sulfide gas as a treatment against P. falciparum, murine cerebral malaria, and the importance of thiolation state in the development of cerebral malaria

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Vis graf over relationer
Cerebral malaria (CM) is a potentially fatal cerebrovascular disease of complex pathogenesis caused by Plasmodium falciparum. Hydrogen sulfide (HS) is a physiological gas, similar to nitric oxide and carbon monoxide, involved in cellular metabolism, vascular tension, inflammation, and cell death. HS treatment has shown promising results as a therapy for cardio- and neuro- pathology. This study investigates the effects of fast (NaHS) and slow (GYY4137) HS-releasing drugs on the growth and metabolism of P. falciparum and the development of P. berghei ANKA CM. Moreover, we investigate the role of free plasma thiols and cell surface thiols in the pathogenesis of CM.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind8
Udgave nummer3
Sider (fra-til)e59271
ISSN1932-6203
DOI
StatusUdgivet - 26 mar. 2013

ID: 42499375