Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Investigating circadian clock gene expression in human tendon biopsies from acute exercise and immobilization studies

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The physiology of rowing with perspective on training and health

    Publikation: Bidrag til tidsskriftReviewpeer review

  2. Ultrasound speckle tracking of Achilles tendon in individuals with unilateral tendinopathy: a pilot study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Elevated arterial lactate delays recovery of intracellular muscle pH after exercise

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Biomechanical properties of the patellar tendon in children with heritable connective tissue disorders

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. UTE T2* mapping of tendinopathic patellar tendons: an MRI reproducibility study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Insulin-stimulated glucose uptake partly relies on p21-activated kinase (PAK)2, but not PAK1, in mouse skeletal muscle

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. No detectable remodelling in adult human menisci: an analysis based on the C14 bomb pulse

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

PURPOSE: The discovery of musculoskeletal tissues, including muscle, tendons, and cartilage, as peripheral circadian clocks strongly implicates their role in tissue-specific homeostasis. Age-related dampening and misalignment of the tendon circadian rhythm and its outputs may be responsible for the decline in tendon homeostasis. It is unknown which entrainment signals are responsible for the synchronization of the tendon clock to the light-dark cycle.

METHODS: We sought to examine any changes in the expression levels of core clock genes (BMAL1, CLOCK, PER2, CRY1, and NR1D1) in healthy human patellar tendon biopsies obtained from three different intervention studies: increased physical activity (leg kicks for 1 h) in young, reduced activity (2 weeks immobilization of one leg) in young, and in old tendons.

RESULTS: The expression level of clock genes in human tendon in vivo was very low and a high variation between individuals was found. We were thus unable to detect any differences in core clock gene expression neither after acute exercise nor immobilization.

CONCLUSIONS: We are unable to find evidence for an effect of exercise or immobilization on circadian clock gene expression in human tendon samples.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Applied Physiology
Vol/bind119
Udgave nummer6
Sider (fra-til)1387-1394
Antal sider8
ISSN1439-6319
DOI
StatusUdgivet - jun. 2019

ID: 59363134