Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Inverse Cross-sectional and Longitudinal Relationships between Diabetic Retinopathy and Obstructive Sleep Apnea in Type 2 Diabetes: Results from a National Screening Program

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Quantifying surgical skill in macular surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Topical anaesthesia in strabismus surgery for Graves' orbitopathy: a comparative study of 111 patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Viral and Genomic Drivers of Squamous Cell Neoplasms Arising in the Lacrimal Drainage System

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Purpose
In previous smaller studies, associations were demonstrated between diabetic retinopathy (DR) and obstructive sleep apnea (OSA), but longitudinal relationships have not been evaluated in larger cohorts. The aim of the present study was to assess the cross-sectional and prospective associations between DR and OSA in a national cohort of patients with type 2 diabetes.

Design
Cross-sectional and 5-year longitudinal registry-based cohort study.

Participants
For cases, we included 153 238 patients with type 2 diabetes who had attended diabetic eye screening and were registered in the Danish Registry of Diabetic Retinopathy (DiaBase). Each of these were matched by 5 control participants without diabetes of the same age and gender (n = 746 148).

Methods
Exposure and outcome data as well as systemic morbidity and use of medications were identified in national registers, including the DiaBase, the Danish National Patient Register, the Danish National Prescription Registry, and the Danish Civil Registration System. The index date was defined as the date of the first DR screening registered in DiaBase.

Main Outcome Measures
Exposure was defined as present and level-specific DR, and main outcomes were crude, age- and gender-adjusted, and multivariable adjusted odds ratios (ORs) for prevalent OSA as well as hazard ratios (HR) for 5-year incident OSA and DR.

Results
Patients with type 2 diabetes independently were more likely to have prevalent OSA (OR, 2.01; 95% confidence interval [CI], 1.95–2.08) and to develop OSA within 5 years (HR, 1.55; 95% CI, 1.46–1.64). Patients with type 2 diabetes and DR at baseline were less likely to have prevalent OSA (OR, 0.57; 95% CI, 0.52–0.62) or to demonstrate incident OSA (HR, 0.86; 95% CI, 0.74–0.99). Likewise, patients with OSA had a lower risk to develop DR (HR, 0.83; 95% CI, 0.74–0.92).

Conclusions
In a registry-based national cohort study, patients with type 2 diabetes had a higher risk of OSA. However, a 43% decreased risk of prevalent OSA was demonstrated in patients with DR, and prospectively, OSA and DR both were related inversely with each other.
OriginalsprogEngelsk
TidsskriftOphthalmology Science
Vol/bind1
Udgave nummer1
Sider (fra-til)1-9
Antal sider9
ISSN2666-9145
StatusUdgivet - 2022

ID: 70637888