Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

In-utero Exposure to Maternal Stressful Life Events and Risk of Cryptorchidism: The Raine Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

APA

Bräuner, E., Hickey, M., Hansen, Å. M., Doherty, D. A., Handelsman, D. J., Juul, A., & Hart, R. (2019). In-utero Exposure to Maternal Stressful Life Events and Risk of Cryptorchidism: The Raine Study. Frontiers in Endocrinology, 10, 530.

CBE

MLA

Vancouver

Author

Bräuner, Elvira ; Hickey, Martha ; Hansen, Åse Marie ; Doherty, Dorota A ; Handelsman, D J ; Juul, Anders ; Hart, Roger. / In-utero Exposure to Maternal Stressful Life Events and Risk of Cryptorchidism: The Raine Study. I: Frontiers in Endocrinology. 2019 ; Bind 10. s. 530.

Bibtex

@article{9f9b452b4bd448faa8c3709102f21736,
title = "In-utero Exposure to Maternal Stressful Life Events and Risk of Cryptorchidism: The Raine Study",
abstract = "Cryptorchidism, registered at birth or later, is the most common birth defect in males in western countries, estimated to affect around 2-3{\%} of newborn boys, declining to around 2{\%} at 3 months. We have previously described a potential association between stressful life events (SLEs) in pregnancy and reduced semen quality and testosterone levels in adult offspring. Both outcomes are believed to share a common etiology with cryptorchidism thus increased risk of cryptorchidism in boys exposed to prenatal SLEs may be plausible. The risk of cryptorchidism associated with prenatal SLE amongst 1273 male Generation 2 offspring was estimated using the Western Australian Pregnancy (Raine) Study. SLEs are discrete experiences that disrupt an individualG{\cC}{\"O}s usual activities causing a life change and readjustment, such as death of a relative or friend, divorce, illness or job loss. Mothers prospectively reported SLEs, during pregnancy at gestational weeks (GW) 18 and 34 using a standardized 10-point questionnaire. A boy was diagnosed as cryptorchid if one or both testes was non-palpable in the scrotum and not able to be manipulated into the scrotum. Twenty-four (2{\%}) cryptorchid boys were identified. Mean (standard deviation) of SLE exposures in GW34 was 1.1 (1.2) for non-cryptorchid boys and slightly higher 1.5 (1.8) for cryptorchid boys, similar differences were observed in GW18. Adjusted odds ratio [OR] and 95{\%} confidence intervals (CI) for risk of cryptorchidism in early (18-weeks) and late gestation (34-weeks) according to prenatal SLE exposures were: 1.06 (95{\%} CI: 0.77-1.45) and 1.18 (95{\%} CI: 0.84-1.67), respectively. This is the first-time report on the possible relationships between exposure to early and late pregnancy SLEs and risk of cryptorchidism in a birth cohort. Prenatal SLE exposure was not associated with a statistically significant increase in the risk of cryptorchidism in male offspring. A small case population limits the statistical power of the study and future larger studies are required to evaluate this potential association",
author = "Elvira Br{\"a}uner and Martha Hickey and Hansen, {{\AA}se Marie} and Doherty, {Dorota A} and Handelsman, {D J} and Anders Juul and Roger Hart",
year = "2019",
language = "English",
volume = "10",
pages = "530",
journal = "Frontiers in Endocrinology",
issn = "1664-2392",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - In-utero Exposure to Maternal Stressful Life Events and Risk of Cryptorchidism: The Raine Study

AU - Bräuner, Elvira

AU - Hickey, Martha

AU - Hansen, Åse Marie

AU - Doherty, Dorota A

AU - Handelsman, D J

AU - Juul, Anders

AU - Hart, Roger

PY - 2019

Y1 - 2019

N2 - Cryptorchidism, registered at birth or later, is the most common birth defect in males in western countries, estimated to affect around 2-3% of newborn boys, declining to around 2% at 3 months. We have previously described a potential association between stressful life events (SLEs) in pregnancy and reduced semen quality and testosterone levels in adult offspring. Both outcomes are believed to share a common etiology with cryptorchidism thus increased risk of cryptorchidism in boys exposed to prenatal SLEs may be plausible. The risk of cryptorchidism associated with prenatal SLE amongst 1273 male Generation 2 offspring was estimated using the Western Australian Pregnancy (Raine) Study. SLEs are discrete experiences that disrupt an individualGÇÖs usual activities causing a life change and readjustment, such as death of a relative or friend, divorce, illness or job loss. Mothers prospectively reported SLEs, during pregnancy at gestational weeks (GW) 18 and 34 using a standardized 10-point questionnaire. A boy was diagnosed as cryptorchid if one or both testes was non-palpable in the scrotum and not able to be manipulated into the scrotum. Twenty-four (2%) cryptorchid boys were identified. Mean (standard deviation) of SLE exposures in GW34 was 1.1 (1.2) for non-cryptorchid boys and slightly higher 1.5 (1.8) for cryptorchid boys, similar differences were observed in GW18. Adjusted odds ratio [OR] and 95% confidence intervals (CI) for risk of cryptorchidism in early (18-weeks) and late gestation (34-weeks) according to prenatal SLE exposures were: 1.06 (95% CI: 0.77-1.45) and 1.18 (95% CI: 0.84-1.67), respectively. This is the first-time report on the possible relationships between exposure to early and late pregnancy SLEs and risk of cryptorchidism in a birth cohort. Prenatal SLE exposure was not associated with a statistically significant increase in the risk of cryptorchidism in male offspring. A small case population limits the statistical power of the study and future larger studies are required to evaluate this potential association

AB - Cryptorchidism, registered at birth or later, is the most common birth defect in males in western countries, estimated to affect around 2-3% of newborn boys, declining to around 2% at 3 months. We have previously described a potential association between stressful life events (SLEs) in pregnancy and reduced semen quality and testosterone levels in adult offspring. Both outcomes are believed to share a common etiology with cryptorchidism thus increased risk of cryptorchidism in boys exposed to prenatal SLEs may be plausible. The risk of cryptorchidism associated with prenatal SLE amongst 1273 male Generation 2 offspring was estimated using the Western Australian Pregnancy (Raine) Study. SLEs are discrete experiences that disrupt an individualGÇÖs usual activities causing a life change and readjustment, such as death of a relative or friend, divorce, illness or job loss. Mothers prospectively reported SLEs, during pregnancy at gestational weeks (GW) 18 and 34 using a standardized 10-point questionnaire. A boy was diagnosed as cryptorchid if one or both testes was non-palpable in the scrotum and not able to be manipulated into the scrotum. Twenty-four (2%) cryptorchid boys were identified. Mean (standard deviation) of SLE exposures in GW34 was 1.1 (1.2) for non-cryptorchid boys and slightly higher 1.5 (1.8) for cryptorchid boys, similar differences were observed in GW18. Adjusted odds ratio [OR] and 95% confidence intervals (CI) for risk of cryptorchidism in early (18-weeks) and late gestation (34-weeks) according to prenatal SLE exposures were: 1.06 (95% CI: 0.77-1.45) and 1.18 (95% CI: 0.84-1.67), respectively. This is the first-time report on the possible relationships between exposure to early and late pregnancy SLEs and risk of cryptorchidism in a birth cohort. Prenatal SLE exposure was not associated with a statistically significant increase in the risk of cryptorchidism in male offspring. A small case population limits the statistical power of the study and future larger studies are required to evaluate this potential association

M3 - Journal article

VL - 10

SP - 530

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

ER -

ID: 57757600