Intrinsic asthma and bacterial histamine release

S Norn, P Stahl Skov, C Kock, P Andersen, M Pedersen, P Tønnesen, P S Pedersen, N E Møller, J Hertz, N Høiby

Abstract

In this study of intrinsic asthma (IA) in children the pathogenic role of bacteria in respiratory disease was elucidated by a basophil histamine liberation technique. Several strains of bacteria caused release of histamine from peripheral leukocytes in vitro. Normal, non-infectious and non-atopic children frequently responded in a similar fashion, although positive responses were less frequent. It seems that two different mechanisms of bacterial histamine release exist: interaction with the basophil-bound IgE and a direct interaction with the cell surface. It is suggested that the histamine release takes place only in the lung of IA patients, where a defective pulmonary barrier could permit the bacteria to enter, but not in healthy individuals.

OriginalsprogEngelsk
TidsskriftAgents and Actions
Vol/bind12
Udgave nummer1-2
Sider (fra-til)101-2
Antal sider2
ISSN0065-4299
DOI
StatusUdgivet - apr. 1982
Udgivet eksterntJa

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