Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Intravenous saline administration in patients with severe acquired brain injury and orthostatic intolerance for tilt-table mobilization

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Relatives of patients with severe brain injury: Growth curve analysis of anxiety and depression the first year after injury

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Family needs in the chronic phase after severe brain injury in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Patients with the most severe traumatic brain injury benefit from rehabilitation

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  4. Depression, anxiety and quality-of-life among relatives of patients with severe brain injury: the acute phase

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Traumatic brain injury and olfactory deficits: the tale of two smell tests!

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

PRIMARY OBJECTIVE: This study aimed to investigate the effect of intravenous saline administration on orthostatic hypotension (OH) during head up tilt (HUT) and the change in the renin-angiotensin-aldosterone system before and after HUT in patients with severe acquired brain injury (ABI).

RESEARCH DESIGN: The study is designed as an observational study.

METHODS AND PROCEDURES: Fourteen patients with ABI, low level of consciousness and OH were monitored before, during and after HUT with non-invasive beat-to-beat blood pressure measurement, and transcranial Doppler determination of middle cerebral artery blood flow velocity. Blood samples were collected before and after two HUT sessions separated by 1 hour and saline was administered in between.

MAIN OUTCOMES AND RESULTS: Patients' ability to stand upright did not change after saline administration due to OH. The patients showed signs of reduced cerebral autoregulation at both HUT sessions. The patients had a significant lower level of renin and angiotensin II but not aldosterone.

CONCLUSIONS: Patients with severe ABI and OH demonstrate no improvement in standing time with reduced plasma renin and angiotensin II after two HUT sessions and 1 hour fluid administration. Research focusing on the ability to retain fluid after bed rest is warranted.

OriginalsprogEngelsk
TidsskriftBrain Injury
Vol/bind32
Udgave nummer2
Sider (fra-til)252-256
Antal sider5
ISSN0269-9052
DOI
StatusUdgivet - 2018

ID: 52225158