TY - JOUR
T1 - Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat
AU - Kristensen, David Møbjerg
AU - Hass, Ulla
AU - Lesné, Laurianne
AU - Poulsen, Grete Lottrup
AU - Jacobsen, Pernille Rosenskjold
AU - Desdoits-Lethimonier, Christele
AU - Boberg, Julie
AU - Petersen, Jørgen Holm
AU - Toppari, Jorma
AU - Jensen, Tina Kold
AU - Brunak, Søren
AU - Skakkebaek, Niels E
AU - Nellemann, Christine
AU - Main, Katharina M
AU - Jégou, Bernard
AU - Leffers, Henrik
PY - 2011/1/1
Y1 - 2011/1/1
N2 - More than half of pregnant women in the Western world report intake of mild analgesics, and some of these drugs have been associated with anti-androgenic effects in animal experiments. Intrauterine exposure to anti-androgens is suspected to contribute to the recent increase in male reproductive problems, and many of the anti-androgenic compounds are like the mild analgesics potent inhibitors of prostaglandin synthesis. Therefore, it appears imperative to further investigate the potential endocrine disrupting properties of mild analgesics.
AB - More than half of pregnant women in the Western world report intake of mild analgesics, and some of these drugs have been associated with anti-androgenic effects in animal experiments. Intrauterine exposure to anti-androgens is suspected to contribute to the recent increase in male reproductive problems, and many of the anti-androgenic compounds are like the mild analgesics potent inhibitors of prostaglandin synthesis. Therefore, it appears imperative to further investigate the potential endocrine disrupting properties of mild analgesics.
U2 - 10.1093/humrep/deq323
DO - 10.1093/humrep/deq323
M3 - Journal article
C2 - 21059752
SN - 0268-1161
VL - 26
SP - 235
EP - 244
JO - Human Reproduction
JF - Human Reproduction
IS - 1
ER -