Intrathecal IgG synthesis and autoantibody-secreting cells in multiple sclerosis.

Finn Sellebjerg, Claus V Jensen, Michael Christiansen

37 Citationer (Scopus)

Abstract

We studied intrathecal IgG synthesis and autoantibody-secreting cells in 148 patients with possible onset symptoms of MS (POSMS) or clinically definite MS (CDMS). In POSMS intrathecal synthesis of IgG oligoclonal bands and abnormalities on T2-weighted magnetic resonance imaging were associated but the former were more prevalent. The cerebrospinal fluid (CSF) leukocyte count and the number of anti-protelipid protein antibody-secreting cells in cerebrospinal fluid (CSF) correlated with disease activity in POSMS. Intrathecal IgG synthesis levels and the number of anti-myelin basic protein antibody-secreting cells in CSF correlated with disease activity in CDMS. Our results support recent reports of pathogenetic heterogeneity and a pathogenetic role of the antibody response in MS
OriginalsprogEngelsk
TidsskriftJ Neuroimmunol
Vol/bind108
Udgave nummer1-2
Sider (fra-til)207-215
StatusUdgivet - 2000

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