Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Intranasal corticosteroids compared with oral antihistamines in allergic rhinitis: A systematic review and meta-analysis

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Injection of Steroid in Nasal Polyps: A Systematic Review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Sinus bacteriology in patients with cystic fibrosis or primary ciliary dyskinesia: A systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Asthma in ear, nose, and throat primary care patients with chronic rhinosinusitis with nasal polyps

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Management of chronic rhinosinusitis with nasal polyps and coexisting asthma: A systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The molecular profile of mucosal melanoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genetic Biomarkers in Melanoma of the Ocular Region: What the Medical Oncologist Should Know

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Isolated Ocular Sarcoidosis Mimicking Ring Melanoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Loss of retinal tension and permanent decrease in retinal function: a new porcine model of rhegmatogenous retinal detachment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Intranasal corticosteroids (INS) (corticosteroid nasal sprays) and oral antihistamines (OA) are two of the most common treatments for patients with allergic rhinitis (AR). To our knowledge, there are no systematic reviews on this topic including trials published after 2007.

OBJECTIVE: To compare INS with nonsedating OAs as treatments for AR.

METHODS: The systematic review and meta-analysis were based on the Grades of Recommendation, Assessment, Development, and Evaluation principles and the Patient, Intervention, Comparison, and Outcome approach. Primary literature was searched up to January 22, 2015. Criteria for eligibility were randomized controlled trials that compared the efficacy and/or adverse effects of INS and OA in patients with AR. Continuous outcome data were analyzed by using standardized mean differences (SMD) for multiple outcome measures, and mean differences in the case of a single study or outcome. Pooled estimates of effects, 95% confidence interval (CI), were calculated by using random-effects models.

RESULTS: The meta-analysis included five randomized controlled trials with a total of 990 patients. INS were superior to OAs in improving total nasal symptoms score (SMD -0.70 [95% CI, -0.93 to -0.47]) and in relieving the following: nasal obstruction (SMD -0.56 [95% CI, -0.82 to -0.29]), rhinorrhea (SMD -0.47 [95% CI, -1.00 to 0.05]), nasal itching (SMD -0.42 [95% CI, -0.65 to -0.18]), sneezing (SMD -0.52 [95% CI, -0.73 to -0.32]), and quality of life mean difference -0.90 [95% CI, -1.18 to -0.62]). There was no difference in relief of ocular symptoms (SMD -0.08 [95% CI, -0.23 to 0.08]). In addition, four randomized controlled trials were included in a narrative analysis. The results in the narrative analysis were comparable with those found in the meta-analysis.

CONCLUSION: INS were superior to OAs in improving nasal symptoms and quality of life in patients with AR.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Rhinology and Allergy
Vol/bind31
Udgave nummer1
Sider (fra-til)19-28
Antal sider10
ISSN1945-8924
DOI
StatusUdgivet - 9 jan. 2017

ID: 52765172