Intralesional triamcinolone for flares of hidradenitis suppurativa (HS): A case series

Peter Theut Riis; Jurr Boer; Errol P Prens; Ditte M L Saunte; Inge E Deckers; Lennart Emtestam; Karin Sartorius; Gregor B E Jemec

doi:10.1016/j.jaad.2016.06.049

Intralesional triamcinolone for flares of hidradenitis suppurativa (HS): A case series

Peter Theut Riis, Jurr Boer, Errol P Prens, Ditte M L Saunte, Inge E Deckers, Lennart Emtestam, Karin Sartorius, Gregor B E Jemec

83 Citationer (Scopus)

Abstract

BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle. Standard practice of managing acute flares with corticosteroid injection lacks scientific evidence.

OBJECTIVE: We sought to assess the outcomes of routine treatment using intralesional triamcinolone (triamcinolone acetonide 10 mg/mL) in the management of acute flares in HS.

METHODS: This was a prospective case series evaluating the effect of intralesional corticosteroids for alleviation of acute flares in HS. Physician- and patient-reported outcomes were noted.

RESULTS: Significant reductions in physician-assessed erythema (median score from 2-1, P < .0001), edema (median score from 2-1, P < .0001), suppuration (median score from 2-1, P < .0001), and size (median score from 3-1, P < .0001) was demonstrated at follow-up. A significant difference in patient-reported pain visual analog scale scores occurred after 1 day (from 5.5-2.3, P < .005) and from day 1 to day 2 (from 2.3-1.4, P < .002).

LIMITATIONS: Small study size, open single-arm design, and short follow-up time are the limitations of this study.

CONCLUSION: Intralesional injection of corticosteroids is perceived as beneficial by physicians and patients in the management of HS flares by reducing pain after 1 day and signs of inflammation approximately 7 days later.

Originalsprog	Engelsk
Tidsskrift	Journal of the American Academy of Dermatology
Vol/bind	75
Udgave nummer	6
Sider (fra-til)	1151-1155
Antal sider	5
ISSN	0190-9622
DOI	https://doi.org/10.1016/j.jaad.2016.06.049
Status	Udgivet - dec. 2016
Udgivet eksternt	Ja

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10.1016/j.jaad.2016.06.049

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@article{456c04ddfc2e4972a53ae7abe6c8bdc0,

title = "Intralesional triamcinolone for flares of hidradenitis suppurativa (HS): A case series",

abstract = "BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle. Standard practice of managing acute flares with corticosteroid injection lacks scientific evidence.OBJECTIVE: We sought to assess the outcomes of routine treatment using intralesional triamcinolone (triamcinolone acetonide 10 mg/mL) in the management of acute flares in HS.METHODS: This was a prospective case series evaluating the effect of intralesional corticosteroids for alleviation of acute flares in HS. Physician- and patient-reported outcomes were noted.RESULTS: Significant reductions in physician-assessed erythema (median score from 2-1, P < .0001), edema (median score from 2-1, P < .0001), suppuration (median score from 2-1, P < .0001), and size (median score from 3-1, P < .0001) was demonstrated at follow-up. A significant difference in patient-reported pain visual analog scale scores occurred after 1 day (from 5.5-2.3, P < .005) and from day 1 to day 2 (from 2.3-1.4, P < .002).LIMITATIONS: Small study size, open single-arm design, and short follow-up time are the limitations of this study.CONCLUSION: Intralesional injection of corticosteroids is perceived as beneficial by physicians and patients in the management of HS flares by reducing pain after 1 day and signs of inflammation approximately 7 days later.",

keywords = "Adult, Anti-Inflammatory Agents/administration & dosage, Edema/etiology, Erythema/etiology, Hidradenitis Suppurativa/complications, Humans, Injections, Intralesional, Pain/etiology, Prospective Studies, Severity of Illness Index, Suppuration/etiology, Treatment Outcome, Triamcinolone/administration & dosage",

author = "Riis, {Peter Theut} and Jurr Boer and Prens, {Errol P} and Saunte, {Ditte M L} and Deckers, {Inge E} and Lennart Emtestam and Karin Sartorius and Jemec, {Gregor B E}",

year = "2016",

month = dec,

doi = "10.1016/j.jaad.2016.06.049",

language = "English",

volume = "75",

pages = "1151--1155",

journal = "Journal of the American Academy of Dermatology",

issn = "0190-9622",

publisher = "Mosby, Inc",

number = "6",

}

TY - JOUR

T1 - Intralesional triamcinolone for flares of hidradenitis suppurativa (HS)

T2 - A case series

AU - Riis, Peter Theut

AU - Boer, Jurr

AU - Prens, Errol P

AU - Saunte, Ditte M L

AU - Deckers, Inge E

AU - Emtestam, Lennart

AU - Sartorius, Karin

AU - Jemec, Gregor B E

PY - 2016/12

Y1 - 2016/12

N2 - BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle. Standard practice of managing acute flares with corticosteroid injection lacks scientific evidence.OBJECTIVE: We sought to assess the outcomes of routine treatment using intralesional triamcinolone (triamcinolone acetonide 10 mg/mL) in the management of acute flares in HS.METHODS: This was a prospective case series evaluating the effect of intralesional corticosteroids for alleviation of acute flares in HS. Physician- and patient-reported outcomes were noted.RESULTS: Significant reductions in physician-assessed erythema (median score from 2-1, P < .0001), edema (median score from 2-1, P < .0001), suppuration (median score from 2-1, P < .0001), and size (median score from 3-1, P < .0001) was demonstrated at follow-up. A significant difference in patient-reported pain visual analog scale scores occurred after 1 day (from 5.5-2.3, P < .005) and from day 1 to day 2 (from 2.3-1.4, P < .002).LIMITATIONS: Small study size, open single-arm design, and short follow-up time are the limitations of this study.CONCLUSION: Intralesional injection of corticosteroids is perceived as beneficial by physicians and patients in the management of HS flares by reducing pain after 1 day and signs of inflammation approximately 7 days later.

AB - BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle. Standard practice of managing acute flares with corticosteroid injection lacks scientific evidence.OBJECTIVE: We sought to assess the outcomes of routine treatment using intralesional triamcinolone (triamcinolone acetonide 10 mg/mL) in the management of acute flares in HS.METHODS: This was a prospective case series evaluating the effect of intralesional corticosteroids for alleviation of acute flares in HS. Physician- and patient-reported outcomes were noted.RESULTS: Significant reductions in physician-assessed erythema (median score from 2-1, P < .0001), edema (median score from 2-1, P < .0001), suppuration (median score from 2-1, P < .0001), and size (median score from 3-1, P < .0001) was demonstrated at follow-up. A significant difference in patient-reported pain visual analog scale scores occurred after 1 day (from 5.5-2.3, P < .005) and from day 1 to day 2 (from 2.3-1.4, P < .002).LIMITATIONS: Small study size, open single-arm design, and short follow-up time are the limitations of this study.CONCLUSION: Intralesional injection of corticosteroids is perceived as beneficial by physicians and patients in the management of HS flares by reducing pain after 1 day and signs of inflammation approximately 7 days later.

KW - Adult

KW - Anti-Inflammatory Agents/administration & dosage

KW - Edema/etiology

KW - Erythema/etiology

KW - Hidradenitis Suppurativa/complications

KW - Humans

KW - Injections, Intralesional

KW - Pain/etiology

KW - Prospective Studies

KW - Severity of Illness Index

KW - Suppuration/etiology

KW - Treatment Outcome

KW - Triamcinolone/administration & dosage

U2 - 10.1016/j.jaad.2016.06.049

DO - 10.1016/j.jaad.2016.06.049

M3 - Journal article

C2 - 27692735

SN - 0190-9622

VL - 75

SP - 1151

EP - 1155

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 6

ER -

Intralesional triamcinolone for flares of hidradenitis suppurativa (HS): A case series

Abstract

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