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Region Hovedstaden - en del af Københavns Universitetshospital

Interventions targeted at oxidatively generated modifications of nucleic acids focused on urine and plasma markers

Publikation: Bidrag til tidsskriftReviewpeer review

  1. Urinary markers of nucleic acid oxidation increase with age, obesity and insulin resistance in Danish children and adolescents

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The Effect of Different Training Intensities on Oxidatively Generated Modifications of Nucleic Acids: A Randomized, Controlled Trial

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

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  2. Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography

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Vis graf over relationer

Oxidative stress is associated with the development and progression of numerous diseases. However, targeting oxidative stress has not been established in the clinical management of any disease. Several methods and markers are available to measure oxidative stress, including direct measurement of free radicals, antioxidants, redox balance, and oxidative modifications of cellular macromolecules. Oxidatively generated nucleic acid modifications have attracted much interest due to the pre-mutagenic oxidative modification of DNA into 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), associated with cancer development. During the last decade, the perception of RNA has changed from that of a ‘silent messenger’ to an ‘active contributor’, and, parallelly oxidatively generated RNA modifications measured as 8-oxo-7,8-dihydro-guanosine (8-oxoGuo), has been demonstrated as a prognostic factor for all-caused and cardiovascular related mortality in patients with type 2 diabetes. Several attempts have been made to modify the amount of oxidative nucleic acid modifications. Thus, this review aims to introduce researchers to the measurement of oxidatively generated nucleic acid modifications as well as critically review previous attempts and provide future directions for targeting oxidatively generated nucleic acid modifications.

TidsskriftFree Radical Biology & Medicine
Sider (fra-til)256-283
Antal sider28
StatusUdgivet - dec. 2019

ID: 58036901