Interstitial lung abnormalities in people with HIV infection and uninfected controls

Andreas Ronit; Thomas Benfield; Jens Lundgren; Jørgen Vestbo; Shoaib Afzal; Børge G Nordestgaard; Jørgen Tobias Kühl; Klaus F Kofoed; Susanne Dam Nielsen; Thomas Kristensen

doi:10.1093/infdis/jiaa047

Interstitial lung abnormalities in people with HIV infection and uninfected controls

Andreas Ronit, Thomas Benfield, Jens Lundgren, Jørgen Vestbo, Shoaib Afzal, Børge G Nordestgaard, Jørgen Tobias Kühl, Klaus F Kofoed, Susanne Dam Nielsen, Thomas Kristensen

12 Citationer (Scopus)

Abstract

BACKGROUND: Chest computed tomography (CT) findings in well-treated people with HIV infection (PWH) remain poorly characterized. METHODS: Cross-sectional analysis examining interstitial chest CT findings in PWH (n = 754) and uninfected controls (n = 470). RESULTS: HIV infection was independently associated with 1.82 (95% CI, 1.18-2.88) and 5.15 (95% CI, 1.72-22.2) higher adjusted odds of any interstitial lung abnormality and findings suspicious for interstitial lung disease, respectively. CONCLUSIONS: HIV infection was independently associated with interstitial lung abnormalities and findings suspicious for interstitial lung disease. Whether these abnormalities develop into more recognizable disease states over time is unknown but warrants further investigation.

Originalsprog	Engelsk
Tidsskrift	The Journal of infectious diseases
Vol/bind	221
Udgave nummer	12
Sider (fra-til)	1973-1977
Antal sider	5
ISSN	0022-1899
DOI	https://doi.org/10.1093/infdis/jiaa047
Status	Udgivet - 15 jun. 2020

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10.1093/infdis/jiaa047

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title = "Interstitial lung abnormalities in people with HIV infection and uninfected controls",

abstract = "BACKGROUND: Chest computed tomography (CT) findings in well-treated people with HIV infection (PWH) remain poorly characterized. METHODS: Cross-sectional analysis examining interstitial chest CT findings in PWH (n = 754) and uninfected controls (n = 470). RESULTS: HIV infection was independently associated with 1.82 (95% CI, 1.18-2.88) and 5.15 (95% CI, 1.72-22.2) higher adjusted odds of any interstitial lung abnormality and findings suspicious for interstitial lung disease, respectively. CONCLUSIONS: HIV infection was independently associated with interstitial lung abnormalities and findings suspicious for interstitial lung disease. Whether these abnormalities develop into more recognizable disease states over time is unknown but warrants further investigation.",

keywords = "chest CT, HIV, interstitial lung abnormality, interstitial lung disease, lung function",

author = "Andreas Ronit and Thomas Benfield and Jens Lundgren and J{\o}rgen Vestbo and Shoaib Afzal and Nordestgaard, {B{\o}rge G} and K{\"u}hl, {J{\o}rgen Tobias} and Kofoed, {Klaus F} and Nielsen, {Susanne Dam} and Thomas Kristensen",

year = "2020",

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doi = "10.1093/infdis/jiaa047",

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TY - JOUR

T1 - Interstitial lung abnormalities in people with HIV infection and uninfected controls

AU - Ronit, Andreas

AU - Benfield, Thomas

AU - Lundgren, Jens

AU - Vestbo, Jørgen

AU - Afzal, Shoaib

AU - Nordestgaard, Børge G

AU - Kühl, Jørgen Tobias

AU - Kofoed, Klaus F

AU - Nielsen, Susanne Dam

AU - Kristensen, Thomas

PY - 2020/6/15

Y1 - 2020/6/15

N2 - BACKGROUND: Chest computed tomography (CT) findings in well-treated people with HIV infection (PWH) remain poorly characterized. METHODS: Cross-sectional analysis examining interstitial chest CT findings in PWH (n = 754) and uninfected controls (n = 470). RESULTS: HIV infection was independently associated with 1.82 (95% CI, 1.18-2.88) and 5.15 (95% CI, 1.72-22.2) higher adjusted odds of any interstitial lung abnormality and findings suspicious for interstitial lung disease, respectively. CONCLUSIONS: HIV infection was independently associated with interstitial lung abnormalities and findings suspicious for interstitial lung disease. Whether these abnormalities develop into more recognizable disease states over time is unknown but warrants further investigation.

AB - BACKGROUND: Chest computed tomography (CT) findings in well-treated people with HIV infection (PWH) remain poorly characterized. METHODS: Cross-sectional analysis examining interstitial chest CT findings in PWH (n = 754) and uninfected controls (n = 470). RESULTS: HIV infection was independently associated with 1.82 (95% CI, 1.18-2.88) and 5.15 (95% CI, 1.72-22.2) higher adjusted odds of any interstitial lung abnormality and findings suspicious for interstitial lung disease, respectively. CONCLUSIONS: HIV infection was independently associated with interstitial lung abnormalities and findings suspicious for interstitial lung disease. Whether these abnormalities develop into more recognizable disease states over time is unknown but warrants further investigation.

KW - chest CT

KW - HIV

KW - interstitial lung abnormality

KW - interstitial lung disease

KW - lung function

UR - http://www.scopus.com/inward/record.url?scp=85086419427&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiaa047

DO - 10.1093/infdis/jiaa047

M3 - Journal article

C2 - 32002544

SN - 0022-1899

VL - 221

SP - 1973

EP - 1977

JO - The Journal of infectious diseases

JF - The Journal of infectious diseases

IS - 12

ER -

Interstitial lung abnormalities in people with HIV infection and uninfected controls

Abstract

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