TY - JOUR
T1 - Interstitial lung abnormalities in people with HIV infection and uninfected controls
AU - Ronit, Andreas
AU - Benfield, Thomas
AU - Lundgren, Jens
AU - Vestbo, Jørgen
AU - Afzal, Shoaib
AU - Nordestgaard, Børge G
AU - Kühl, Jørgen Tobias
AU - Kofoed, Klaus F
AU - Nielsen, Susanne Dam
AU - Kristensen, Thomas
N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].
PY - 2020/6/15
Y1 - 2020/6/15
N2 - BACKGROUND: Chest computed tomography (CT) findings in well-treated people with HIV infection (PWH) remain poorly characterized. METHODS: Cross-sectional analysis examining interstitial chest CT findings in PWH (n = 754) and uninfected controls (n = 470). RESULTS: HIV infection was independently associated with 1.82 (95% CI, 1.18-2.88) and 5.15 (95% CI, 1.72-22.2) higher adjusted odds of any interstitial lung abnormality and findings suspicious for interstitial lung disease, respectively. CONCLUSIONS: HIV infection was independently associated with interstitial lung abnormalities and findings suspicious for interstitial lung disease. Whether these abnormalities develop into more recognizable disease states over time is unknown but warrants further investigation.
AB - BACKGROUND: Chest computed tomography (CT) findings in well-treated people with HIV infection (PWH) remain poorly characterized. METHODS: Cross-sectional analysis examining interstitial chest CT findings in PWH (n = 754) and uninfected controls (n = 470). RESULTS: HIV infection was independently associated with 1.82 (95% CI, 1.18-2.88) and 5.15 (95% CI, 1.72-22.2) higher adjusted odds of any interstitial lung abnormality and findings suspicious for interstitial lung disease, respectively. CONCLUSIONS: HIV infection was independently associated with interstitial lung abnormalities and findings suspicious for interstitial lung disease. Whether these abnormalities develop into more recognizable disease states over time is unknown but warrants further investigation.
KW - chest CT
KW - HIV
KW - interstitial lung abnormality
KW - interstitial lung disease
KW - lung function
UR - http://www.scopus.com/inward/record.url?scp=85086419427&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiaa047
DO - 10.1093/infdis/jiaa047
M3 - Journal article
C2 - 32002544
SN - 0022-1899
VL - 221
SP - 1973
EP - 1977
JO - The Journal of infectious diseases
JF - The Journal of infectious diseases
IS - 12
ER -