Interstitial cells of Cajal in human gut and gastrointestinal disease

J M Vanderwinden, J J Rumessen

    186 Citationer (Scopus)

    Abstract

    This paper reviews the distribution of interstitial cells of Cajal (ICC) in the human gastrointestinal (GI) tract, based on ultrastructural and immunohistochemical evidence. The distribution and morphology of ICC at each level of the normal GI tracts is addressed from the perspective of their functional significance. Alterations of ICC reported in achalasia of cardia, infantile hypertrophic pyloric stenosis, chronic intestinal pseudoobstruction, Hirschsprung's disease, inflammatory bowel diseases, slow transit constipation, and some other disorders of GI motility as well as in gastrointestinal stromal tumors are reviewed, with emphasis on the place of ICC in the pathophysiology of disease.
    OriginalsprogEngelsk
    TidsskriftMicroscopy Research and Technique
    Vol/bind47
    Udgave nummer5
    Sider (fra-til)344-60
    Antal sider17
    ISSN1059-910X
    DOI
    StatusUdgivet - 1 dec. 1999

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