International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Gothenburg, Barcelona and four virtual business meetings: Update on blood group systems

Catherine A. Hyland; Lilian Castilho; Qing Chen; Frederik Banch Clausen; Gregory A. Denomme; Yann Fichou; Willy Albert Flegel; Aline Floch; Nicholas Gleadall; Åsa Hellberg; Yanli Ji; Vanja Karamatic Crew; Margaret A. Keller; William J. Lane; Peter C. Ligthart; Christine Lomas-Francis; Genghis H. Lopez; Celina Montemayor; Núria Nogués; Gorka Ochoa; Martin L. Olsson; Thierry Peyrard; Kshitij Srivastava; Jill R. Storry; Yoshihiko Tani; Nicole Thornton; Ellen van der Schoot; Sunitha Vege; Barbera Veldhuisen; Franz F. Wagner; Christof Weinstock; Silvano Wendel; Connie M. Westhoff; Vered Yahalom; Christoph Gassner

doi:10.1111/vox.70148

International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Gothenburg, Barcelona and four virtual business meetings: Update on blood group systems

Catherine A. Hyland^*, Lilian Castilho, Qing Chen, Frederik Banch Clausen, Gregory A. Denomme, Yann Fichou, Willy Albert Flegel, Aline Floch, Nicholas Gleadall, Åsa Hellberg, Yanli Ji, Vanja Karamatic Crew, Margaret A. Keller, William J. Lane, Peter C. Ligthart, Christine Lomas-Francis, Genghis H. Lopez, Celina Montemayor, Núria Nogués, Gorka OchoaMartin L. Olsson, Thierry Peyrard, Kshitij Srivastava, Jill R. Storry, Yoshihiko Tani, Nicole Thornton, Ellen van der Schoot, Sunitha Vege, Barbera Veldhuisen, Franz F. Wagner, Christof Weinstock, Silvano Wendel, Connie M. Westhoff, Vered Yahalom, Christoph Gassner

^*Corresponding author af dette arbejde

Afdeling for Klinisk Immunologi DIA

Abstract

Background and Objectives: The International Society of Blood Transfusion (ISBT) Working Party (WP) on Red Cell Immunogenetics and Blood Group Terminology (RCI&BGT) held six business meetings between December 2021 and June 2024. This report describes the new blood group systems and antigens ratified during these meetings. Materials and Methods: Candidate systems and antigens were reviewed according to serological, genetic and biological evidence. This evidence was matched against defined criteria, and the acknowledged systems/antigens were assigned a unique identifier. Results: Four new systems, ER (ISBT 044), CD36 (ISBT 045), ATP11C (ISBT 046) and MAL (ISBT 047), were ratified. CD36 and ATP11C were de novo entries, while ER and MAL systems resolved the genetic basis for the Er and AnWj antigens. Thirteen antigens were added to existing systems: one each to LU (005), YT (011), SC (013), LW (016), KN (022), GLOB (028); an antithetical pair to KEL (006); two antigens to RHAG (030); and three to CTL2 (039). Two CTL2 antigens defined the hitherto unresolved antithetical antigens, Cs^a/Cs^b, whose genetic basis coincides with those of variants responsible for the HNA-3a/3b neutrophil antigens, respectively. Conclusion: As of June 2024, the ISBT has acknowledged 47 blood group systems, comprising 366 antigens. The WP continues to ratify new systems and antigens, which are available on the ISBT website (http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology/).

Originalsprog	Engelsk
Tidsskrift	Vox Sanguinis
ISSN	0042-9007
DOI	https://doi.org/10.1111/vox.70148
Status	E-pub ahead of print - 1 dec. 2025

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10.1111/vox.70148

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Citationsformater

Hyland, C. A., Castilho, L., Chen, Q., Clausen, F. B., Denomme, G. A., Fichou, Y., Flegel, W. A., Floch, A., Gleadall, N., Hellberg, Å., Ji, Y., Karamatic Crew, V., Keller, M. A., Lane, W. J., Ligthart, P. C., Lomas-Francis, C., Lopez, G. H., Montemayor, C., Nogués, N., ... Gassner, C. (2025). International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Gothenburg, Barcelona and four virtual business meetings: Update on blood group systems. Vox Sanguinis. Advance online publication. https://doi.org/10.1111/vox.70148

International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Gothenburg, Barcelona and four virtual business meetings: Update on blood group systems. / Hyland, Catherine A.; Castilho, Lilian; Chen, Qing et al.
I: Vox Sanguinis, 01.12.2025.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Hyland, CA, Castilho, L, Chen, Q, Clausen, FB, Denomme, GA, Fichou, Y, Flegel, WA, Floch, A, Gleadall, N, Hellberg, Å, Ji, Y, Karamatic Crew, V, Keller, MA, Lane, WJ, Ligthart, PC, Lomas-Francis, C, Lopez, GH, Montemayor, C, Nogués, N, Ochoa, G, Olsson, ML, Peyrard, T, Srivastava, K, Storry, JR, Tani, Y, Thornton, N, van der Schoot, E, Vege, S, Veldhuisen, B, Wagner, FF, Weinstock, C, Wendel, S, Westhoff, CM, Yahalom, V & Gassner, C 2025, 'International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Gothenburg, Barcelona and four virtual business meetings: Update on blood group systems', Vox Sanguinis. https://doi.org/10.1111/vox.70148

@article{4e5b6a37d6724519ae1aaeae57d90f08,

title = "International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Gothenburg, Barcelona and four virtual business meetings: Update on blood group systems",

abstract = "Background and Objectives: The International Society of Blood Transfusion (ISBT) Working Party (WP) on Red Cell Immunogenetics and Blood Group Terminology (RCI&BGT) held six business meetings between December 2021 and June 2024. This report describes the new blood group systems and antigens ratified during these meetings. Materials and Methods: Candidate systems and antigens were reviewed according to serological, genetic and biological evidence. This evidence was matched against defined criteria, and the acknowledged systems/antigens were assigned a unique identifier. Results: Four new systems, ER (ISBT 044), CD36 (ISBT 045), ATP11C (ISBT 046) and MAL (ISBT 047), were ratified. CD36 and ATP11C were de novo entries, while ER and MAL systems resolved the genetic basis for the Er and AnWj antigens. Thirteen antigens were added to existing systems: one each to LU (005), YT (011), SC (013), LW (016), KN (022), GLOB (028); an antithetical pair to KEL (006); two antigens to RHAG (030); and three to CTL2 (039). Two CTL2 antigens defined the hitherto unresolved antithetical antigens, Csa/Csb, whose genetic basis coincides with those of variants responsible for the HNA-3a/3b neutrophil antigens, respectively. Conclusion: As of June 2024, the ISBT has acknowledged 47 blood group systems, comprising 366 antigens. The WP continues to ratify new systems and antigens, which are available on the ISBT website (http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology/).",

keywords = "blood groups, genetics, genomics, red cell antigens, terminology",

author = "Hyland, {Catherine A.} and Lilian Castilho and Qing Chen and Clausen, {Frederik Banch} and Denomme, {Gregory A.} and Yann Fichou and Flegel, {Willy Albert} and Aline Floch and Nicholas Gleadall and {\AA}sa Hellberg and Yanli Ji and {Karamatic Crew}, Vanja and Keller, {Margaret A.} and Lane, {William J.} and Ligthart, {Peter C.} and Christine Lomas-Francis and Lopez, {Genghis H.} and Celina Montemayor and N{\'u}ria Nogu{\'e}s and Gorka Ochoa and Olsson, {Martin L.} and Thierry Peyrard and Kshitij Srivastava and Storry, {Jill R.} and Yoshihiko Tani and Nicole Thornton and {van der Schoot}, Ellen and Sunitha Vege and Barbera Veldhuisen and Wagner, {Franz F.} and Christof Weinstock and Silvano Wendel and Westhoff, {Connie M.} and Vered Yahalom and Christoph Gassner",

note = "Publisher Copyright: {\textcopyright} 2025 International Society of Blood Transfusion.",

year = "2025",

month = dec,

day = "1",

doi = "10.1111/vox.70148",

language = "English",

journal = "Vox Sanguinis",

issn = "0042-9007",

publisher = "Wiley-Blackwell Publishing Ltd",

}

TY - JOUR

T1 - International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Gothenburg, Barcelona and four virtual business meetings

T2 - Update on blood group systems

AU - Hyland, Catherine A.

AU - Castilho, Lilian

AU - Chen, Qing

AU - Clausen, Frederik Banch

AU - Denomme, Gregory A.

AU - Fichou, Yann

AU - Flegel, Willy Albert

AU - Floch, Aline

AU - Gleadall, Nicholas

AU - Hellberg, Åsa

AU - Ji, Yanli

AU - Karamatic Crew, Vanja

AU - Keller, Margaret A.

AU - Lane, William J.

AU - Ligthart, Peter C.

AU - Lomas-Francis, Christine

AU - Lopez, Genghis H.

AU - Montemayor, Celina

AU - Nogués, Núria

AU - Ochoa, Gorka

AU - Olsson, Martin L.

AU - Peyrard, Thierry

AU - Srivastava, Kshitij

AU - Storry, Jill R.

AU - Tani, Yoshihiko

AU - Thornton, Nicole

AU - van der Schoot, Ellen

AU - Vege, Sunitha

AU - Veldhuisen, Barbera

AU - Wagner, Franz F.

AU - Weinstock, Christof

AU - Wendel, Silvano

AU - Westhoff, Connie M.

AU - Yahalom, Vered

AU - Gassner, Christoph

PY - 2025/12/1

Y1 - 2025/12/1

N2 - Background and Objectives: The International Society of Blood Transfusion (ISBT) Working Party (WP) on Red Cell Immunogenetics and Blood Group Terminology (RCI&BGT) held six business meetings between December 2021 and June 2024. This report describes the new blood group systems and antigens ratified during these meetings. Materials and Methods: Candidate systems and antigens were reviewed according to serological, genetic and biological evidence. This evidence was matched against defined criteria, and the acknowledged systems/antigens were assigned a unique identifier. Results: Four new systems, ER (ISBT 044), CD36 (ISBT 045), ATP11C (ISBT 046) and MAL (ISBT 047), were ratified. CD36 and ATP11C were de novo entries, while ER and MAL systems resolved the genetic basis for the Er and AnWj antigens. Thirteen antigens were added to existing systems: one each to LU (005), YT (011), SC (013), LW (016), KN (022), GLOB (028); an antithetical pair to KEL (006); two antigens to RHAG (030); and three to CTL2 (039). Two CTL2 antigens defined the hitherto unresolved antithetical antigens, Csa/Csb, whose genetic basis coincides with those of variants responsible for the HNA-3a/3b neutrophil antigens, respectively. Conclusion: As of June 2024, the ISBT has acknowledged 47 blood group systems, comprising 366 antigens. The WP continues to ratify new systems and antigens, which are available on the ISBT website (http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology/).

AB - Background and Objectives: The International Society of Blood Transfusion (ISBT) Working Party (WP) on Red Cell Immunogenetics and Blood Group Terminology (RCI&BGT) held six business meetings between December 2021 and June 2024. This report describes the new blood group systems and antigens ratified during these meetings. Materials and Methods: Candidate systems and antigens were reviewed according to serological, genetic and biological evidence. This evidence was matched against defined criteria, and the acknowledged systems/antigens were assigned a unique identifier. Results: Four new systems, ER (ISBT 044), CD36 (ISBT 045), ATP11C (ISBT 046) and MAL (ISBT 047), were ratified. CD36 and ATP11C were de novo entries, while ER and MAL systems resolved the genetic basis for the Er and AnWj antigens. Thirteen antigens were added to existing systems: one each to LU (005), YT (011), SC (013), LW (016), KN (022), GLOB (028); an antithetical pair to KEL (006); two antigens to RHAG (030); and three to CTL2 (039). Two CTL2 antigens defined the hitherto unresolved antithetical antigens, Csa/Csb, whose genetic basis coincides with those of variants responsible for the HNA-3a/3b neutrophil antigens, respectively. Conclusion: As of June 2024, the ISBT has acknowledged 47 blood group systems, comprising 366 antigens. The WP continues to ratify new systems and antigens, which are available on the ISBT website (http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology/).

KW - blood groups

KW - genetics

KW - genomics

KW - red cell antigens

KW - terminology

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U2 - 10.1111/vox.70148

DO - 10.1111/vox.70148

M3 - Journal article

C2 - 41326325

AN - SCOPUS:105023514130

SN - 0042-9007

JO - Vox Sanguinis

JF - Vox Sanguinis

ER -