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International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Adaptive Trial Designs in Rheumatology: Report from the OMERACT Special Interest Group

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. OMERACT Development of a Core Domain Set of Outcomes for Shared Decision-making Interventions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Ana-Maria Orbai
  • Maarten de Wit
  • Philip Mease
  • Judy A Shea
  • Laure Gossec
  • Ying Ying Leung
  • William Tillett
  • Musaab Elmamoun
  • Kristina Callis Duffin
  • Willemina Campbell
  • Robin Christensen
  • Laura Coates
  • Emma Dures
  • Lihi Eder
  • Oliver FitzGerald
  • Dafna Gladman
  • Niti Goel
  • Suzanne Dolwick Grieb
  • Sarah Hewlett
  • Pil Hoejgaard
  • Umut Kalyoncu
  • Chris Lindsay
  • Neil McHugh
  • Bev Shea
  • Ingrid Steinkoenig
  • Vibeke Strand
  • Alexis Ogdie
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OBJECTIVE: To identify a core set of domains (outcomes) to be measured in psoriatic arthritis (PsA) clinical trials that represent both patients' and physicians' priorities.

METHODS: We conducted (1) a systematic literature review (SLR) of domains assessed in PsA; (2) international focus groups to identify domains important to people with PsA; (3) two international surveys with patients and physicians to prioritise domains; (4) an international face-to-face meeting with patients and physicians using the nominal group technique method to agree on the most important domains; and (5) presentation and votes at the Outcome Measures in Rheumatology (OMERACT) conference in May 2016. All phases were performed in collaboration with patient research partners.

RESULTS: We identified 39 unique domains through the SLR (24 domains) and international focus groups (34 domains). 50 patients and 75 physicians rated domain importance. During the March 2016 consensus meeting, 12 patients and 12 physicians agreed on 10 candidate domains. Then, 49 patients and 71 physicians rated these domains' importance. Five were important to >70% of both groups: musculoskeletal disease activity, skin disease activity, structural damage, pain and physical function. Fatigue and participation were important to >70% of patients. Patient global and systemic inflammation were important to >70% of physicians. The updated PsA core domain set endorsed by 90% of OMERACT 2016 participants includes musculoskeletal disease activity, skin disease activity, pain, patient global, physical function, health-related quality of life, fatigue and systemic inflammation.

CONCLUSIONS: The updated PsA core domain set incorporates patients' and physicians' priorities and evolving PsA research. Next steps include identifying outcome measures that adequately assess these domains.

TidsskriftAnnals of the Rheumatic Diseases
Udgave nummer4
Sider (fra-til)673-680
Antal sider8
StatusUdgivet - apr. 2017

ID: 52010290