TY - JOUR
T1 - International Consensus for ultrasound lesions in gout
T2 - results of Delphi process and web-reliability exercise
AU - Gutierrez, Marwin
AU - Schmidt, Wolfgang A
AU - Thiele, Ralf G
AU - Keen, Helen I
AU - Kaeley, Gurjit S
AU - Naredo, Esperanza
AU - Iagnocco, Annamaria
AU - Bruyn, George A
AU - Balint, Peter V
AU - Filippucci, Emilio
AU - Mandl, Peter
AU - Kane, David
AU - Pineda, Carlos
AU - Delle Sedie, Andrea
AU - Hammer, Hilde Berner
AU - Christensen, Robin
AU - D'Agostino, Maria Antonietta
AU - Terslev, Lene
AU - OMERACT Ultrasound Gout Task Force group
N1 - COPECARE
PY - 2015/10
Y1 - 2015/10
N2 - OBJECTIVE: To produce consensus-based definitions of the US elementary lesions in gout and to test their reliability in a web-based exercise.METHODS: The process consisted of two steps. In the first step a written Delphi questionnaire was developed from a systematic literature review and expert international consensus. This collated information resulted in four statements defining US elementary lesions: double contour (DC), tophus, aggregates and erosion. The Delphi questionnaire was sent to 35 rheumatology experts in US, asking them to rate their level of agreement or disagreement with each statement. The second step tested the reliability by a web-exercise. US images of both normal and gouty elementary lesions were collected by the participants. A facilitator then constructed an electronic database of 110 images. The database was sent to the participants, who evaluated the presence/absence of US elementary lesions. A group of 20 images was displayed twice to evaluate intra-reader reliability.RESULTS: A total of 32 participants responded to the questionnaires. Good agreement (>80%) was obtained for US definitions on DC, tophus, aggregates and erosion in the Delphi exercise after three rounds. The reliability on images showed inter-reader κ values for DC, tophus, aggregates, erosion findings of 0.98, 0.71, 0.54 and 0.85, respectively. The mean intra-reader κ values were also acceptable: 0.93, 0.78, 0.65 and 0.78, respectively.CONCLUSION: This, the first consensus-based US definition of elementary lesions in gout, demonstrated good reliability overall. It constitutes an essential step in developing a core outcome measurement that permits a higher degree of homogeneity and comparability between multicentre studies.
AB - OBJECTIVE: To produce consensus-based definitions of the US elementary lesions in gout and to test their reliability in a web-based exercise.METHODS: The process consisted of two steps. In the first step a written Delphi questionnaire was developed from a systematic literature review and expert international consensus. This collated information resulted in four statements defining US elementary lesions: double contour (DC), tophus, aggregates and erosion. The Delphi questionnaire was sent to 35 rheumatology experts in US, asking them to rate their level of agreement or disagreement with each statement. The second step tested the reliability by a web-exercise. US images of both normal and gouty elementary lesions were collected by the participants. A facilitator then constructed an electronic database of 110 images. The database was sent to the participants, who evaluated the presence/absence of US elementary lesions. A group of 20 images was displayed twice to evaluate intra-reader reliability.RESULTS: A total of 32 participants responded to the questionnaires. Good agreement (>80%) was obtained for US definitions on DC, tophus, aggregates and erosion in the Delphi exercise after three rounds. The reliability on images showed inter-reader κ values for DC, tophus, aggregates, erosion findings of 0.98, 0.71, 0.54 and 0.85, respectively. The mean intra-reader κ values were also acceptable: 0.93, 0.78, 0.65 and 0.78, respectively.CONCLUSION: This, the first consensus-based US definition of elementary lesions in gout, demonstrated good reliability overall. It constitutes an essential step in developing a core outcome measurement that permits a higher degree of homogeneity and comparability between multicentre studies.
U2 - 10.1093/rheumatology/kev112
DO - 10.1093/rheumatology/kev112
M3 - Journal article
C2 - 25972391
SN - 1462-0324
VL - 54
SP - 1797
EP - 1805
JO - Rheumatology (Oxford, England)
JF - Rheumatology (Oxford, England)
IS - 10
ER -