Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Nadeem Sarwar; Adam S Butterworth; Daniel F Freitag; John Gregson; Peter Willeit; Donal N Gorman; Pei Gao; Danish Saleheen; Augusto Rendon; Christopher P Nelson; Peter S Braund; Alistair S Hall; Daniel I Chasman; Anne Tybjærg-Hansen; John C Chambers; Emelia J Benjamin; Paul W Franks; Robert Clarke; Arthur A M Wilde; Mieke D Trip; Maristella Steri; Jacqueline C M Witteman; Lu Qi; C Ellen van der Schoot; Ulf de Faire; Jeanette Erdmann; Heather M Stringham; Wolfgang Koenig; Daniel J Rader; David Melzer; David Reich; Bruce M Psaty; Marcus E Kleber; Demosthenes B Panagiotakos; Johann Willeit; Patrik Wennberg; Mark Woodward; Svetlana Adamovic; Eric B Rimm; Tom W Meade; Richard F Gillum; Jonathan A Shaffer; Albert Hofman; Altan Onat; Johan Sundström; Sylvia Wassertheil-Smoller; Dan Mellström; John Gallacher; Kristine H Allin; Børge G Nordestgaard; IL6R Genetics Consortium Emerging Risk Factors Collaboration

doi:10.1016/S0140-6736(11)61931-4

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Nadeem Sarwar, Adam S Butterworth, Daniel F Freitag, John Gregson, Peter Willeit, Donal N Gorman, Pei Gao, Danish Saleheen, Augusto Rendon, Christopher P Nelson, Peter S Braund, Alistair S Hall, Daniel I Chasman, Anne Tybjærg-Hansen, John C Chambers, Emelia J Benjamin, Paul W Franks, Robert Clarke, Arthur A M Wilde, Mieke D TripMaristella Steri, Jacqueline C M Witteman, Lu Qi, C Ellen van der Schoot, Ulf de Faire, Jeanette Erdmann, Heather M Stringham, Wolfgang Koenig, Daniel J Rader, David Melzer, David Reich, Bruce M Psaty, Marcus E Kleber, Demosthenes B Panagiotakos, Johann Willeit, Patrik Wennberg, Mark Woodward, Svetlana Adamovic, Eric B Rimm, Tom W Meade, Richard F Gillum, Jonathan A Shaffer, Albert Hofman, Altan Onat, Johan Sundström, Sylvia Wassertheil-Smoller, Dan Mellström, John Gallacher, Kristine H Allin, Børge G Nordestgaard, IL6R Genetics Consortium Emerging Risk Factors Collaboration

Afdeling for Klinisk Biokemi

685 Citationer (Scopus)

Abstract

Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.

Originalsprog	Engelsk
Tidsskrift	Lancet
Vol/bind	379
Udgave nummer	9822
Sider (fra-til)	1205-13
Antal sider	9
ISSN	0140-6736
DOI	https://doi.org/10.1016/S0140-6736(11)61931-4
Status	Udgivet - 2012

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10.1016/S0140-6736(11)61931-4

Citationsformater

Sarwar, N., Butterworth, A. S., Freitag, D. F., Gregson, J., Willeit, P., Gorman, D. N., Gao, P., Saleheen, D., Rendon, A., Nelson, C. P., Braund, P. S., Hall, A. S., Chasman, D. I., Tybjærg-Hansen, A., Chambers, J. C., Benjamin, E. J., Franks, P. W., Clarke, R., Wilde, A. A. M., ... IL6R Genetics Consortium Emerging Risk Factors Collaboration (2012). Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet, 379(9822), 1205-13. https://doi.org/10.1016/S0140-6736(11)61931-4

Sarwar, N, Butterworth, AS, Freitag, DF, Gregson, J, Willeit, P, Gorman, DN, Gao, P, Saleheen, D, Rendon, A, Nelson, CP, Braund, PS, Hall, AS, Chasman, DI, Tybjærg-Hansen, A, Chambers, JC, Benjamin, EJ, Franks, PW, Clarke, R, Wilde, AAM, Trip, MD, Steri, M, Witteman, JCM, Qi, L, van der Schoot, CE, de Faire, U, Erdmann, J, Stringham, HM, Koenig, W, Rader, DJ, Melzer, D, Reich, D, Psaty, BM, Kleber, ME, Panagiotakos, DB, Willeit, J, Wennberg, P, Woodward, M, Adamovic, S, Rimm, EB, Meade, TW, Gillum, RF, Shaffer, JA, Hofman, A, Onat, A, Sundström, J, Wassertheil-Smoller, S, Mellström, D, Gallacher, J, Allin, KH, Nordestgaard, BG & IL6R Genetics Consortium Emerging Risk Factors Collaboration 2012, 'Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies', Lancet, bind 379, nr. 9822, s. 1205-13. https://doi.org/10.1016/S0140-6736(11)61931-4

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title = "Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies",

abstract = "Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.",

keywords = "Causality, Coronary Disease, Gene Frequency, Genetic Variation, Humans, Inflammation Mediators, Receptors, Interleukin-6, Risk Factors, Signal Transduction",

author = "Nadeem Sarwar and Butterworth, {Adam S} and Freitag, {Daniel F} and John Gregson and Peter Willeit and Gorman, {Donal N} and Pei Gao and Danish Saleheen and Augusto Rendon and Nelson, {Christopher P} and Braund, {Peter S} and Hall, {Alistair S} and Chasman, {Daniel I} and Anne Tybj{\ae}rg-Hansen and Chambers, {John C} and Benjamin, {Emelia J} and Franks, {Paul W} and Robert Clarke and Wilde, {Arthur A M} and Trip, {Mieke D} and Maristella Steri and Witteman, {Jacqueline C M} and Lu Qi and {van der Schoot}, {C Ellen} and {de Faire}, Ulf and Jeanette Erdmann and Stringham, {Heather M} and Wolfgang Koenig and Rader, {Daniel J} and David Melzer and David Reich and Psaty, {Bruce M} and Kleber, {Marcus E} and Panagiotakos, {Demosthenes B} and Johann Willeit and Patrik Wennberg and Mark Woodward and Svetlana Adamovic and Rimm, {Eric B} and Meade, {Tom W} and Gillum, {Richard F} and Shaffer, {Jonathan A} and Albert Hofman and Altan Onat and Johan Sundstr{\"o}m and Sylvia Wassertheil-Smoller and Dan Mellstr{\"o}m and John Gallacher and Allin, {Kristine H} and Nordestgaard, {B{\o}rge G} and {IL6R Genetics Consortium Emerging Risk Factors Collaboration}",

year = "2012",

doi = "10.1016/S0140-6736(11)61931-4",

language = "English",

volume = "379",

pages = "1205--13",

journal = "Lancet",

issn = "0140-6736",

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TY - JOUR

T1 - Interleukin-6 receptor pathways in coronary heart disease

T2 - a collaborative meta-analysis of 82 studies

AU - Sarwar, Nadeem

AU - Butterworth, Adam S

AU - Freitag, Daniel F

AU - Gregson, John

AU - Willeit, Peter

AU - Gorman, Donal N

AU - Gao, Pei

AU - Saleheen, Danish

AU - Rendon, Augusto

AU - Nelson, Christopher P

AU - Braund, Peter S

AU - Hall, Alistair S

AU - Chasman, Daniel I

AU - Tybjærg-Hansen, Anne

AU - Chambers, John C

AU - Benjamin, Emelia J

AU - Franks, Paul W

AU - Clarke, Robert

AU - Wilde, Arthur A M

AU - Trip, Mieke D

AU - Steri, Maristella

AU - Witteman, Jacqueline C M

AU - Qi, Lu

AU - van der Schoot, C Ellen

AU - de Faire, Ulf

AU - Erdmann, Jeanette

AU - Stringham, Heather M

AU - Koenig, Wolfgang

AU - Rader, Daniel J

AU - Melzer, David

AU - Reich, David

AU - Psaty, Bruce M

AU - Kleber, Marcus E

AU - Panagiotakos, Demosthenes B

AU - Willeit, Johann

AU - Wennberg, Patrik

AU - Woodward, Mark

AU - Adamovic, Svetlana

AU - Rimm, Eric B

AU - Meade, Tom W

AU - Gillum, Richard F

AU - Shaffer, Jonathan A

AU - Hofman, Albert

AU - Onat, Altan

AU - Sundström, Johan

AU - Wassertheil-Smoller, Sylvia

AU - Mellström, Dan

AU - Gallacher, John

AU - Allin, Kristine H

AU - Nordestgaard, Børge G

AU - IL6R Genetics Consortium Emerging Risk Factors Collaboration

PY - 2012

Y1 - 2012

N2 - Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.

AB - Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.

KW - Causality

KW - Coronary Disease

KW - Gene Frequency

KW - Genetic Variation

KW - Humans

KW - Inflammation Mediators

KW - Receptors, Interleukin-6

KW - Risk Factors

KW - Signal Transduction

U2 - 10.1016/S0140-6736(11)61931-4

DO - 10.1016/S0140-6736(11)61931-4

M3 - Journal article

C2 - 22421339

SN - 0140-6736

VL - 379

SP - 1205

EP - 1213

JO - Lancet

JF - Lancet

IS - 9822

ER -

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Abstract

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