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Interleukin-1-receptor antagonist in type 2 diabetes mellitus
Claus M Larsen
, Mirjam Faulenbach
,
Allan Vaag
, Aage Vølund
, Jan A Ehses
, Burkhardt Seifert
, Thomas Mandrup-Poulsen
, Marc Y Donath
1641
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Keyphrases
Type 2 Diabetes Mellitus (T2DM)
100%
Interleukin-1 Receptor Antagonist (IL-1Ra)
100%
Anakinra
100%
Interleukin-1β
66%
Insulin
66%
Type 2 Diabetic Patients
66%
C-reactive Protein
33%
Interleukin-6
33%
Body Mass Index
33%
Placebo
33%
Placebo Groups
33%
Glycemia
33%
Proinsulin
33%
Once-daily
33%
β-cell Function
33%
ClinicalTrials.gov
33%
Inflammatory Markers
33%
B Cells
33%
Insulin Resistance
33%
Insulin Sensitivity
33%
Cell Proliferation
33%
Serious Adverse Events
33%
Oral Glucose Tolerance Test
33%
Glycated Hemoglobin
33%
Skeletal muscle
33%
Serum Adiponectin
33%
Parallel Trials
33%
Cell Apoptosis
33%
Intravenous Bolus
33%
Arginine
33%
Hyperinsulinemic-euglycemic Clamp
33%
Gene Regulation
33%
Pancreatic β-cells
33%
Glucagon
33%
High Glucose
33%
Clamp Study
33%
Impaired Insulin Secretion
33%
Glycated Hemoglobin Levels
33%
Pancreatic Islets
33%
C-peptide Secretion
33%
Drug-likeness
33%
Secretory Phase
33%
Systemic Inflammation Markers
33%
Symptomatic Hypoglycemia
33%
Medicine and Dentistry
Maturity Onset Diabetes of the Young
100%
Beta Cell
100%
Interleukin 1 Receptor Blocking Agent
100%
Anakinra
100%
Placebo
66%
Patient with Type 2 Diabetes
66%
Glycated Hemoglobin
66%
Insulin
66%
Glucose
66%
Gene Expression
33%
C Reactive Protein
33%
Programmed Cell Death
33%
Interleukin 1beta
33%
Interleukin 6
33%
Body Mass Index
33%
Proinsulin
33%
Hypoglycemia
33%
Body Weight
33%
Insulin Sensitivity
33%
Cell Function
33%
Insulin Release
33%
Glycemic
33%
C-Peptide
33%
Cell Proliferation
33%
Oral Glucose Tolerance Test
33%
Insulin Resistance
33%
Secretion (Process)
33%
Adipocytokine
33%
Group Trial
33%
Interleukin 1
33%
Pancreatic Islet
33%
Arginine
33%
Glucagon
33%
Inflammation
33%
Skeletal Muscle
33%
Adverse Event
33%