TY - JOUR
T1 - Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control
AU - Bjarnsholt, Thomas
AU - Tolker-Nielsen, Tim
AU - Høiby, Niels
AU - Givskov, Michael
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Pseudomonas aeruginosa is the best described bacterium with regards to quorum sensing (QS), in vitro biofilm formation and the development of antibiotic tolerance. Biofilms composed of P. aeruginosa are thought to be the underlying cause of many chronic infections, including those in wounds and in the lungs of patients with cystic fibrosis. In this review, we provide an overview of the molecular mechanisms involved in QS, QS-enabled virulence, biofilm formation and biofilm-enabled antibiotic tolerance. We now have substantial knowledge of the multicellular behaviour of P. aeruginosa in vitro. A major task for the future is to investigate how such in vitro data correlate with the in vivo behaviour of P. aeruginosa, and how to treat chronic infections of this bacterium in patients.
AB - Pseudomonas aeruginosa is the best described bacterium with regards to quorum sensing (QS), in vitro biofilm formation and the development of antibiotic tolerance. Biofilms composed of P. aeruginosa are thought to be the underlying cause of many chronic infections, including those in wounds and in the lungs of patients with cystic fibrosis. In this review, we provide an overview of the molecular mechanisms involved in QS, QS-enabled virulence, biofilm formation and biofilm-enabled antibiotic tolerance. We now have substantial knowledge of the multicellular behaviour of P. aeruginosa in vitro. A major task for the future is to investigate how such in vitro data correlate with the in vivo behaviour of P. aeruginosa, and how to treat chronic infections of this bacterium in patients.
U2 - 10.1017/S1462399410001420
DO - 10.1017/S1462399410001420
M3 - Review
C2 - 20370936
SN - 1462-3994
VL - 12
SP - e11
JO - Expert Reviews in Molecular Medicine
JF - Expert Reviews in Molecular Medicine
ER -