Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Interactive effects between hemizygous 15q13.3 microdeletion and peripubertal stress on adult behavioral functions

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Sex differences in opioid reinforcement under a fentanyl vs. food choice procedure in rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Effects of clonidine on MMN and P3a amplitude in schizophrenia patients on stable medication

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. In Memoriam: Arvid Carlsson-Pioneering Researcher and Nobel Laureate

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association between Mental Disorders and Subsequent Medical Conditions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Sandra Giovanoli
  • Thomas M Werge
  • Preben B Mortensen
  • Michael Didriksen
  • Urs Meyer
Vis graf over relationer

15q13.3 microdeletion is one of several gene copy number variants (CNVs) conferring increased risk of psychiatric and neurological disorders. This microdeletion gives rise to a variable spectrum of pathological phenotypes, ranging from asymptomatic to severe clinical outcomes. The reasons for these varying phenotypic outcomes remain unknown. Using a mouse model of hemizygous deletion of the orthologous region of 15q13.3, the present study examined whether exposure to stressful life events might interact with hemizygous 15q13.3 microdeletion in the development of behavioral dysfunctions. We show that hemizygous 15q13.3 microdeletion alone induces only limited effects on adult behaviors, but when combined with psychological stress in pubescence (postnatal days 30-40), it impairs sensorimotor gating and increases the sensitivity to the psychostimulant drug, amphetamine, at adult age. Stress exposure in adolescence (postnatal days 50-60) did not induce similar interactions with 15q13.3 microdeletion, but led to impaired emotional learning and memory and social behavior regardless of the genetic background. The present study provides the first evidence for interactive effects between hemizygous 15q13.3 microdeletion and exposure to stressful life events, and at the same time, it emphasizes an important influence of the precise timing of postnatal stress exposure in these interactions. Our findings suggest that hemizygous 15q13.3 microdeletion can act as a "disease primer" that increases the carrier's vulnerability to the detrimental effects of peripubertal stress exposure on adult behaviors.

OriginalsprogEngelsk
TidsskriftNeuropsychopharmacology
ISSN0893-133X
DOI
StatusUdgivet - 27 aug. 2018

ID: 55270058