Interaction between obesity and the NFKB1 - 94ins/delATTG promoter polymorphism in relation to incident acute coronary syndrome: a follow up study in three independent cohorts

Jakob Gerhard Stegger; Erik Berg Schmidt; Tina Landsvig Berentzen; Anne Tjønneland; Ulla Birgitte Vogel; Eric Rimm; Thorkild I A Sørensen; Kim Overvad; Majken Karoline Jensen

doi:10.1371/journal.pone.0063004

Interaction between obesity and the NFKB1 - 94ins/delATTG promoter polymorphism in relation to incident acute coronary syndrome: a follow up study in three independent cohorts

Jakob Gerhard Stegger, Erik Berg Schmidt, Tina Landsvig Berentzen, Anne Tjønneland, Ulla Birgitte Vogel, Eric Rimm, Thorkild I A Sørensen, Kim Overvad, Majken Karoline Jensen

9 Citationer (Scopus)

Abstract

The NF-κB transcription factor family regulates several genes encoding pro-inflammatory and anti-inflammatory proteins in adipose tissues and in atherosclerotic plaques. The deletion variant allele of the NFKB1 - 94ins/delATTG promoter polymorphism leads to lower transcript levels of the p50 subunit, and the variant allele has been associated with the risk of several inflammatory diseases as well as coronary heart disease where inflammation is important in the pathogenesis. The objective of this study was to explore the potential interaction between the NFKB1-94ins/delATTG promoter polymorphism and general, abdominal, and gluteofemoral obesity in relation to the risk of incident acute coronary syndrome (ACS) in three large independent cohorts.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	8
Udgave nummer	5
Sider (fra-til)	e63004
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0063004
Status	Udgivet - 2013

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10.1371/journal.pone.0063004

Citationsformater

Stegger, J. G., Schmidt, E. B., Berentzen, T. L., Tjønneland, A., Vogel, U. B., Rimm, E., Sørensen, T. I. A., Overvad, K., & Jensen, M. K. (2013). Interaction between obesity and the NFKB1 - 94ins/delATTG promoter polymorphism in relation to incident acute coronary syndrome: a follow up study in three independent cohorts. P L o S One, 8(5), e63004. https://doi.org/10.1371/journal.pone.0063004

Interaction between obesity and the NFKB1 - 94ins/delATTG promoter polymorphism in relation to incident acute coronary syndrome: a follow up study in three independent cohorts. / Stegger, Jakob Gerhard; Schmidt, Erik Berg; Berentzen, Tina Landsvig et al.
I: P L o S One, Bind 8, Nr. 5, 2013, s. e63004.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Stegger, JG, Schmidt, EB, Berentzen, TL, Tjønneland, A, Vogel, UB, Rimm, E, Sørensen, TIA, Overvad, K & Jensen, MK 2013, 'Interaction between obesity and the NFKB1 - 94ins/delATTG promoter polymorphism in relation to incident acute coronary syndrome: a follow up study in three independent cohorts', P L o S One, bind 8, nr. 5, s. e63004. https://doi.org/10.1371/journal.pone.0063004

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title = "Interaction between obesity and the NFKB1 - 94ins/delATTG promoter polymorphism in relation to incident acute coronary syndrome: a follow up study in three independent cohorts",

abstract = "The NF-κB transcription factor family regulates several genes encoding pro-inflammatory and anti-inflammatory proteins in adipose tissues and in atherosclerotic plaques. The deletion variant allele of the NFKB1 - 94ins/delATTG promoter polymorphism leads to lower transcript levels of the p50 subunit, and the variant allele has been associated with the risk of several inflammatory diseases as well as coronary heart disease where inflammation is important in the pathogenesis. The objective of this study was to explore the potential interaction between the NFKB1-94ins/delATTG promoter polymorphism and general, abdominal, and gluteofemoral obesity in relation to the risk of incident acute coronary syndrome (ACS) in three large independent cohorts.",

keywords = "Acute Coronary Syndrome, Adult, Aged, Base Sequence, Female, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Mutagenesis, Insertional, NF-kappa B, NF-kappa B p50 Subunit, Obesity, Polymorphism, Genetic, Promoter Regions, Genetic, Prospective Studies, Regression Analysis, Sequence Deletion",

author = "Stegger, {Jakob Gerhard} and Schmidt, {Erik Berg} and Berentzen, {Tina Landsvig} and Anne Tj{\o}nneland and Vogel, {Ulla Birgitte} and Eric Rimm and S{\o}rensen, {Thorkild I A} and Kim Overvad and Jensen, {Majken Karoline}",

year = "2013",

doi = "10.1371/journal.pone.0063004",

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T2 - a follow up study in three independent cohorts

AU - Stegger, Jakob Gerhard

AU - Schmidt, Erik Berg

AU - Berentzen, Tina Landsvig

AU - Tjønneland, Anne

AU - Vogel, Ulla Birgitte

AU - Rimm, Eric

AU - Sørensen, Thorkild I A

AU - Overvad, Kim

AU - Jensen, Majken Karoline

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N2 - The NF-κB transcription factor family regulates several genes encoding pro-inflammatory and anti-inflammatory proteins in adipose tissues and in atherosclerotic plaques. The deletion variant allele of the NFKB1 - 94ins/delATTG promoter polymorphism leads to lower transcript levels of the p50 subunit, and the variant allele has been associated with the risk of several inflammatory diseases as well as coronary heart disease where inflammation is important in the pathogenesis. The objective of this study was to explore the potential interaction between the NFKB1-94ins/delATTG promoter polymorphism and general, abdominal, and gluteofemoral obesity in relation to the risk of incident acute coronary syndrome (ACS) in three large independent cohorts.

AB - The NF-κB transcription factor family regulates several genes encoding pro-inflammatory and anti-inflammatory proteins in adipose tissues and in atherosclerotic plaques. The deletion variant allele of the NFKB1 - 94ins/delATTG promoter polymorphism leads to lower transcript levels of the p50 subunit, and the variant allele has been associated with the risk of several inflammatory diseases as well as coronary heart disease where inflammation is important in the pathogenesis. The objective of this study was to explore the potential interaction between the NFKB1-94ins/delATTG promoter polymorphism and general, abdominal, and gluteofemoral obesity in relation to the risk of incident acute coronary syndrome (ACS) in three large independent cohorts.

KW - Acute Coronary Syndrome

KW - Adult

KW - Aged

KW - Base Sequence

KW - Female

KW - Follow-Up Studies

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Middle Aged

KW - Mutagenesis, Insertional

KW - NF-kappa B

KW - NF-kappa B p50 Subunit

KW - Obesity

KW - Polymorphism, Genetic

KW - Promoter Regions, Genetic

KW - Prospective Studies

KW - Regression Analysis

KW - Sequence Deletion

U2 - 10.1371/journal.pone.0063004

DO - 10.1371/journal.pone.0063004

M3 - Journal article

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SN - 1932-6203

VL - 8

SP - e63004

JO - P L o S One

JF - P L o S One

IS - 5

ER -

Interaction between obesity and the NFKB1 - 94ins/delATTG promoter polymorphism in relation to incident acute coronary syndrome: a follow up study in three independent cohorts

Abstract

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